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<p>Tumor-associated fibroblasts (TAFs) are critical mediators within the tumor microenvironment (TME), influencing cancer progression, metastasis, and resistance to therapy. This review explores the latest advancements in biomaterials and biomedical devices that have revolutionized TAF research, including innovations such as 3D bioprinting, organ-on-a-chip platforms, advanced imaging systems, and multi-omics technologies. These tools enable more precise modeling of TAF interactions within the TME, offering significant potential for personalized cancer research and therapeutic development. To ensure the quality and relevance of this review, only peer-reviewed articles from prestigious databases such as PubMed were included, with a focus on recent studies that highlight novel methodologies or significant findings. The selected works emphasize the intersection of biomaterials and TAF-targeted approaches, bridging fundamental research with translational oncology. The findings highlight the transformative role of biomaterials and biomedical devices in advancing TAF-targeted strategies. By providing actionable insights, this review underscores the potential of these technologies to refine cancer therapies and improve clinical outcomes, paving the way for innovative research in oncology.</p>

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Advanced Biomaterials and Biomedical Devices for Studying Tumor-Associated Fibroblasts: Current Trends, Innovations, and Future Prospects

  • 期刊论文

  • 发表日期：

    2025年2月19日

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  • Noura A. A. Ebrahim,
  • Soliman M. A. Soliman

摘要

Tumor-associated fibroblasts (TAFs) are critical mediators within the tumor microenvironment (TME), influencing cancer progression, metastasis, and resistance to therapy. This review explores the latest advancements in biomaterials and biomedical devices that have revolutionized TAF research, including innovations such as 3D bioprinting, organ-on-a-chip platforms, advanced imaging systems, and multi-omics technologies. These tools enable more precise modeling of TAF interactions within the TME, offering significant potential for personalized cancer research and therapeutic development. To ensure the quality and relevance of this review, only peer-reviewed articles from prestigious databases such as PubMed were included, with a focus on recent studies that highlight novel methodologies or significant findings. The selected works emphasize the intersection of biomaterials and TAF-targeted approaches, bridging fundamental research with translational oncology. The findings highlight the transformative role of biomaterials and biomedical devices in advancing TAF-targeted strategies. By providing actionable insights, this review underscores the potential of these technologies to refine cancer therapies and improve clinical outcomes, paving the way for innovative research in oncology.