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<p>Parkinson’s disease (PD), a progressive neurodegenerative disorder, poses significant challenges to healthcare systems worldwide due to its increasing prevalence and need for early detection to improve patient outcomes. This study introduces a robust diagnostic framework leveraging a multimodal feature selection approach, combining Minimum Redundancy Maximum Relevance (mRMR) with Recursive Feature Elimination (RFE), to optimize predictive accuracy in detecting PD. Using a dataset of 894 instances from the UCI Machine Learning Repository, the framework implemented comprehensive data preprocessing and feature selection techniques to refine input features. The Extra Trees classifier, integrated with the mRMR-RFE multimodal feature selection method, demonstrated superior performance over nine other machine learning models, achieving a perfect accuracy of 100%, with high specificity, sensitivity, precision, and F1 scores. This framework highlights the efficacy of ensemble learning methods and feature optimization in healthcare, ensuring computational efficiency and high predictive reliability. By addressing the challenges of dimensionality reduction and ensuring precise predictions, the proposed model sets a benchmark for machine learning applications in PD diagnosis. The results emphasize the potential of this framework to facilitate early detection and support clinical decision making, with significant implications for advancing AI-driven healthcare systems.</p>

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Exploring Multimodal Framework of Optimized Feature-Based Machine Learning to Revolutionize the Diagnosis of Parkinson’s Disease: AI-Driven Insights

  • 期刊论文

  • 发表日期：

    2025年2月24日

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  • Fahmida Khanom,
  • Rafid Mostafiz,
  • Khandaker Mohammad Mohi Uddin

摘要

Parkinson’s disease (PD), a progressive neurodegenerative disorder, poses significant challenges to healthcare systems worldwide due to its increasing prevalence and need for early detection to improve patient outcomes. This study introduces a robust diagnostic framework leveraging a multimodal feature selection approach, combining Minimum Redundancy Maximum Relevance (mRMR) with Recursive Feature Elimination (RFE), to optimize predictive accuracy in detecting PD. Using a dataset of 894 instances from the UCI Machine Learning Repository, the framework implemented comprehensive data preprocessing and feature selection techniques to refine input features. The Extra Trees classifier, integrated with the mRMR-RFE multimodal feature selection method, demonstrated superior performance over nine other machine learning models, achieving a perfect accuracy of 100%, with high specificity, sensitivity, precision, and F1 scores. This framework highlights the efficacy of ensemble learning methods and feature optimization in healthcare, ensuring computational efficiency and high predictive reliability. By addressing the challenges of dimensionality reduction and ensuring precise predictions, the proposed model sets a benchmark for machine learning applications in PD diagnosis. The results emphasize the potential of this framework to facilitate early detection and support clinical decision making, with significant implications for advancing AI-driven healthcare systems.