Computational Analysis of Electric Stimulus Protocols to Investigate Their Impact on Various Breast Cancer Cells

This study aimed to investigate how different kinds of breast cancer cells react to different electric pulses, with a particular emphasis on nanosecond pulses. Using a mathematical model, the study examined important electroporation characteristics, including transmembrane potential, pore radius, density, conductivity, and permittivity. These measurements shed light on the features of the cells and how small changes in internal electric properties—such as capacitance—affect the way they respond to electroporation. The equations characterizing these properties were solved using the COMSOL Multiphysics Model, which allowed for a thorough comprehension of the dynamics controlling cell membrane permeability under electrical stimulation. Utilizing the COMSOL Multiphysics software, a computational model has been constructed that replicated the electroporation process of breast cancer cells as part of our methodology. The parameters of the model were modified to correspond with the characteristics of diverse breast cancer cell types. With particular attention to the impact of nanosecond electric pulses, pore development has been examined, as transmembrane potential changes, and other relevant physical features. By identifying and comparing the responses of various cancer cell types to these pulses, the simulations furnished a quantitative evaluation of the electroporation’s efficacy.