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<p>Antibiotic resistance genes (ARGs) have emerged as critical pollutants in aquatic environments, posing significant risks to public health and ecosystems. Wastewater treatment plants (WWTPs) are key contributors to the dissemination of ARGs due to the incomplete removal of antibiotics and associated contaminants. Despite growing concerns, limited research has specifically focused on how WWTP discharges influence ARG profiles in receiving waters. This bibliometric analysis of 176 papers (1990-01-01 to 2023-10-31) reveals that the documented impact of WWTP effluents on receiving waters primarily involves the elevated abundance of specific ARGs (e.g., <i>bla</i>NDM, <i>sul1</i>), their facilitation of horizontal gene transfer, and the limited removal efficacy of conventional treatment processes. The field has seen a substantial increase in publications, with China leading global contributions (43 papers), followed by the USA (20) and South Africa (17). Prominent institutions, such as the Chinese Academy of Sciences and Tsinghua University, have demonstrated strong collaborative networks. Key research hotspots include mechanisms of ARG dissemination, the environmental and public health impacts of WWTP effluents, mitigation strategies, and advancements in treatment technologies. Current challenges include the lack of standardized monitoring protocols, the high cost of advanced treatment technologies, and the limited understanding of ARG transfer dynamics. Future research should focus on cost-effective sampling and sequencing methods, enhanced bioinformatics tools, interdisciplinary approaches that integrate the <i>“One Health”</i> framework, and the development of innovative treatment technologies to mitigate ARG contamination. By addressing these challenges and outlining potential pathways for progress, this study provides a comprehensive foundation for guiding future research and supporting the development of sustainable wastewater management practices and effective ARG mitigation strategies. These approaches align with United Nations Sustainable Development Goal 6 (UNSDG-Clean Water), reinforcing the need for globally coordinated action.</p>

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Impact of Wastewater Treatment Plant Effluents on Antibiotic Resistance Gene Profiles in Receiving Waters: A Bibliometric Analysis

  • 期刊论文

  • 发表日期：

    2026年3月18日

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  • Jean Claude Nizeyimana,
  • Yuwen Wang,
  • Mahmoud Gad,
  • Habasi Patrick Manzi,
  • Mingyu Liao,
  • Anyi Hu

摘要

Antibiotic resistance genes (ARGs) have emerged as critical pollutants in aquatic environments, posing significant risks to public health and ecosystems. Wastewater treatment plants (WWTPs) are key contributors to the dissemination of ARGs due to the incomplete removal of antibiotics and associated contaminants. Despite growing concerns, limited research has specifically focused on how WWTP discharges influence ARG profiles in receiving waters. This bibliometric analysis of 176 papers (1990-01-01 to 2023-10-31) reveals that the documented impact of WWTP effluents on receiving waters primarily involves the elevated abundance of specific ARGs (e.g., blaNDM, sul1), their facilitation of horizontal gene transfer, and the limited removal efficacy of conventional treatment processes. The field has seen a substantial increase in publications, with China leading global contributions (43 papers), followed by the USA (20) and South Africa (17). Prominent institutions, such as the Chinese Academy of Sciences and Tsinghua University, have demonstrated strong collaborative networks. Key research hotspots include mechanisms of ARG dissemination, the environmental and public health impacts of WWTP effluents, mitigation strategies, and advancements in treatment technologies. Current challenges include the lack of standardized monitoring protocols, the high cost of advanced treatment technologies, and the limited understanding of ARG transfer dynamics. Future research should focus on cost-effective sampling and sequencing methods, enhanced bioinformatics tools, interdisciplinary approaches that integrate the “One Health” framework, and the development of innovative treatment technologies to mitigate ARG contamination. By addressing these challenges and outlining potential pathways for progress, this study provides a comprehensive foundation for guiding future research and supporting the development of sustainable wastewater management practices and effective ARG mitigation strategies. These approaches align with United Nations Sustainable Development Goal 6 (UNSDG-Clean Water), reinforcing the need for globally coordinated action.