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<p>Nowadays, heavy metal toxicity is becoming a serious public health concern, and it requires an appropriate preventive and treatment strategy. In human population, long-term arsenic metal exposure aggravates the development of cancer and skin diseases. As per the Food and Drug Administration, the allowed level of arsenic content in food and pharmaceutical products is “closer to zero.” Several researchers have significantly correlated the level of arsenic in human tissues to the severity of many diseases, including drug-resistant infections, COVID-19, diabetes mellitus, and disorders of brain, respiratory, reproductive, cardiovascular, and renal systems. Looking at curative approaches, phytoconstituents are known to mitigate arsenic toxicity through multiple mechanisms. Thus, phytochemical investigation against arsenic toxicity has become an important area of health research. The reported cellular mechanisms related to signaling pathway for attenuating arsenic toxicity are very impressive. Accordingly, this review presents the reported mechanisms of arsenic-induced toxicity and its mitigation by various phytoconstituents from in vitro, pre-clinical, and clinical studies. Therefore, this review will provide an optimistic way for researchers to design research on phytopharmaceuticals as attenuators of arsenic-induced toxicity in human population.</p>

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Amelioration of Arsenic Toxicity Using Phytoconstituents: Experimental Evidence, Mechanisms, and Strategies

  • 期刊论文

  • 发表日期：

    2025年2月13日

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  • Pothuraju Naresh,
  • P. Harish Kumar,
  • V. Yaswanth Naik,
  • Deepjyoti Das,
  • M. Mahindran,
  • Vipan K. Parihar,
  • V. Ravichandiran,
  • P. Ramalingam

摘要

Nowadays, heavy metal toxicity is becoming a serious public health concern, and it requires an appropriate preventive and treatment strategy. In human population, long-term arsenic metal exposure aggravates the development of cancer and skin diseases. As per the Food and Drug Administration, the allowed level of arsenic content in food and pharmaceutical products is “closer to zero.” Several researchers have significantly correlated the level of arsenic in human tissues to the severity of many diseases, including drug-resistant infections, COVID-19, diabetes mellitus, and disorders of brain, respiratory, reproductive, cardiovascular, and renal systems. Looking at curative approaches, phytoconstituents are known to mitigate arsenic toxicity through multiple mechanisms. Thus, phytochemical investigation against arsenic toxicity has become an important area of health research. The reported cellular mechanisms related to signaling pathway for attenuating arsenic toxicity are very impressive. Accordingly, this review presents the reported mechanisms of arsenic-induced toxicity and its mitigation by various phytoconstituents from in vitro, pre-clinical, and clinical studies. Therefore, this review will provide an optimistic way for researchers to design research on phytopharmaceuticals as attenuators of arsenic-induced toxicity in human population.