Background <p>Substance use significantly affects both society and the economy. This study analyzes the choice of and expenditure on alcohol, cigarettes, and tobacco-gutka products across socioeconomic and regional groups in India.</p> Methods <p>The study used Consumer Pyramids Household Survey data for the year 2024 and Seemingly Unrelated Regression Method under Conditional Mixed Process settings for the analysis.</p> Results <p>It finds that males, middle-aged people, and larger families are more likely to use these substances and spend more on them. People who are educated, employed, married, or have children are less likely to use them and spend less. Substances use increases with income, but spending is highest in middle-income households. There are clear regional patterns: alcohol use and spending are highest in the Southern states, cigarette use is more common in Central India, and tobacco-gutka use is widespread in Central and Eastern regions. Rural households use more of all substances than urban ones.</p> Conclusion <p>The study suggests that policies should be substance-specific and region-focused. Higher education, family support, workplace programs, and higher taxes can help reduce harmful use of these substances in Indian households.</p>