<p>A key technology to address the growing global water shortage is seawater desalination, particularly in areas with limited freshwater resources. Electrocoagulation is one desalination technique that has drawn interest due to its ability to effectively remove impurities from seawater. This study examined the effectiveness of desalinating seawater via electrocoagulation (EC) using monopolar iron electrodes. Targeted salty seawater forms include total hardness (TH), calcium hardness (Ca⁺⁺), alkalinity, bicarbonate (HCO₃), absolute dissolved solids (TDS), chloride (Cl), and sulphate (SO₄). The effects of the four parameters, which are detention time (<i>T</i>), current intensity (<i>I</i>), pH, and electrode distance (<i>x</i>) on treatment efficiency were investigated. After the analysis of the obtained results, it was found that the optimum values of the used parameters were found to be 2 A for the current intensity, 80&#xa0;min for the retention time, 8 for pH, and 1.5&#xa0;cm for the electrode separating distance. For the ideal parameters, the removal seawater salts efficiencies for TH, Ca⁺⁺, alkalinity, HCO₃, TDS, Cl, and SO₄ were found to be 92, 94.21, 91.2, 92.53, 90.1, 90.01, and 90.89 respectively. Also, general equations were developed to estimate the seawater salts removal, <i>R</i> for given <i>I</i>, and <i>T.</i> The study confirms that the EC system effectively removed salts from seawater.</p>