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<p>Prolonged and extensive use of antibiotics in clinical, veterinary, animal stock, agriculture, and food processing sectors are rendering them least effective. The pipeline for new antibiotics is almost dry, leading to the&#xa0;prevalence of multi-drug resistant (MDR) strains. Bacteriophages are native predators of bacteria and have been conventionally illustrated for the&#xa0;treatment of bacterial infections. However easy and large-scale availability of antibiotics in subsequent decades overshadowed the approach of using bacteriophages for treatment. Modern medicine is profoundly dependent on antibiotics and is now soon approaching an alarming exhaustion of anti-infective options. As a ray of hope, scientists and clinicians contemplate advances in phage application as potential and viable options. Various strategies devised to remodel the potential of bacteriophages prominently include genetically engineered phages wherein the antibacterial efficacy of the phage is enhanced to combat MDR bacteria. While in the&#xa0;case of bacteriophage encoded enzymes, broad spectrum antimicrobial proteins are produced in microbial factories harbouring the encoded genetic material. In this review, we discuss various bacteriophage models that emphasize the success of the phenomenon and recent biotechnological advancements that allow to repurpose bacteriophages as an alternate potential therapeutic approach to control drug resistance.</p>

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Bacteriophage therapy inspired new age technologies to control antimicrobial resistance

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月18日

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  • Rujuta Chavan,
  • Krupa Purandare

摘要

Prolonged and extensive use of antibiotics in clinical, veterinary, animal stock, agriculture, and food processing sectors are rendering them least effective. The pipeline for new antibiotics is almost dry, leading to the prevalence of multi-drug resistant (MDR) strains. Bacteriophages are native predators of bacteria and have been conventionally illustrated for the treatment of bacterial infections. However easy and large-scale availability of antibiotics in subsequent decades overshadowed the approach of using bacteriophages for treatment. Modern medicine is profoundly dependent on antibiotics and is now soon approaching an alarming exhaustion of anti-infective options. As a ray of hope, scientists and clinicians contemplate advances in phage application as potential and viable options. Various strategies devised to remodel the potential of bacteriophages prominently include genetically engineered phages wherein the antibacterial efficacy of the phage is enhanced to combat MDR bacteria. While in the case of bacteriophage encoded enzymes, broad spectrum antimicrobial proteins are produced in microbial factories harbouring the encoded genetic material. In this review, we discuss various bacteriophage models that emphasize the success of the phenomenon and recent biotechnological advancements that allow to repurpose bacteriophages as an alternate potential therapeutic approach to control drug resistance.