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<p>The widespread use of plastic-based medical materials, such as bandages, syringes, and biomedical packaging, has led to serious health problems owing to their inappropriate disposal and non-biodegradability. This study focused on the fabrication and characterization of potato-starch-based films infused with amoxicillin-loaded CuONPs (AMX-CuONPs) for biomedical applications. CuONPs were synthesized using <i>Bacopa monnieri</i> leaf extract, which was functionalized with amoxicillin. The properties of the bio-nanocomposite films were characterized morphologically (SEM and EDX), mechanically (tensile strength and elongation at break), structurally (XRD and FTIR), and for biodegradability and antimicrobial activity. The AMX-CuONPs bio-nanocomposite film (AC-BF) exhibited a thickness of 0.69&#xa0;mm, density of 1.33&#xa0;g/cm<sup>3</sup>, tensile strength of 0.63&#xa0;MPa, and the highest elongation break of 49%. XRD analysis revealed the amorphous nature of the film, while FTIR analysis revealed the functional groups such as C-H, O-H, C = O, C = C, and Cu-O, indicating AMX-CuONPs integration into the starch-based films. SEM analysis showed homogeneity and particles embedded on the surface of AC-BF. Furthermore, AC-BF showed rapid biodegradation within 35 days, whereas the maximum zone of inhibition was observed in Antimicrobial Resistance (AMR) and non-AMR bacterial strains. These results suggest the potential of these materials for biomedical packaging, wound healing bandages, and patch applications.</p> Graphical abstract <p></p>

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Starch-based bionanocomposite films infused with amoxicillin-loaded CuO nanoparticles and their enhanced antimicrobial activity against AMR pathogens

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月9日

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  • Avani Thakkar,
  • Tisha Darji,
  • Gautam Priyadarshi,
  • Bhakti Patel,
  • Suhas Vyas,
  • Akanksha Patel,
  • Alijon Khusanov,
  • Sherzodbek Tashbaev,
  • Snehal Bagatharia,
  • Ashish Patel

摘要

The widespread use of plastic-based medical materials, such as bandages, syringes, and biomedical packaging, has led to serious health problems owing to their inappropriate disposal and non-biodegradability. This study focused on the fabrication and characterization of potato-starch-based films infused with amoxicillin-loaded CuONPs (AMX-CuONPs) for biomedical applications. CuONPs were synthesized using Bacopa monnieri leaf extract, which was functionalized with amoxicillin. The properties of the bio-nanocomposite films were characterized morphologically (SEM and EDX), mechanically (tensile strength and elongation at break), structurally (XRD and FTIR), and for biodegradability and antimicrobial activity. The AMX-CuONPs bio-nanocomposite film (AC-BF) exhibited a thickness of 0.69 mm, density of 1.33 g/cm3, tensile strength of 0.63 MPa, and the highest elongation break of 49%. XRD analysis revealed the amorphous nature of the film, while FTIR analysis revealed the functional groups such as C-H, O-H, C = O, C = C, and Cu-O, indicating AMX-CuONPs integration into the starch-based films. SEM analysis showed homogeneity and particles embedded on the surface of AC-BF. Furthermore, AC-BF showed rapid biodegradation within 35 days, whereas the maximum zone of inhibition was observed in Antimicrobial Resistance (AMR) and non-AMR bacterial strains. These results suggest the potential of these materials for biomedical packaging, wound healing bandages, and patch applications.

Graphical abstract