<p>Smart fabric E-Textiles define an important breakthrough in fabric material with thermal comfort and nanotechnology technologies functionalities, and has largely brought revolutions in the smart healthcare industry. The obstruction of sensing, response, and communication of physiological information in real-time is achieved by integrating a smart material into a fabric with biomedical sensors that sense, respond, and communicate with any of a variety of ambient situations. Moreover, E-Textiles made of smart fabrics can be combined with nanomaterials may significantly increase the textile properties by onboard biosensing, thermal, drug delivery and energy harvesting processes. In this case, the thermal comfort and the functionalities of nanotechnology are known to be a turning point in allowing advancements on the realism and acceptability of smart fabric E-Textiles by the stakeholders. The key concerns that have been identified in the creation of smart fabric E-Textile is the achievement of the best balance between the electrical performance, comfort, wearability, and durability. This survey research paper will be a comparative study on the different fabric’s materials investigated in the recent research studies regarding smart fabric E-Textile technology and used in the context of healthcare. Therefore, the survey identifies the existing gaps in the research and suggests the future investigate instructions in the sphere of smart fabric E-Textiles in medical care applications (human fall prediction) introducing sustainable fabric materials, fabrication methods, multifunctional sensing, energy harvesting, wearable therapy, and real-time monitoring.</p>