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<p>With the aim to improve local cancer radiotherapy while maintaining the tissue-regenerative properties of the glass, bioglasses with the composition (58 − <i>x</i>)SiO<sub>2</sub>–36CaO–6P<sub>2</sub>O<sub>5</sub>–<i>x</i>Bi<sub>2</sub>O<sub>3</sub> (where <i>x</i> = 0, 2, 5, or 10 wt%) were synthesized using the sol-gel method. The obtained glasses were labeled as BG, 2Bi-BG, 5Bi-BG, and 10Bi-BG, respectively. Numerous characterization techniques, including XRD, FTIR, SEM-EDX, and DLS were utilized. MTT, fluorescence microscopy, and flow cytometry were used to assess biocompatibility, osteointegration, and sensitization enhancement ratio (SER), respectively, after bismuth addition. A broad hump centered at 12° 2θ, indicating the amorphous, glassy nature of the products. Doped samples showed additional weak reflections confirming the presence of Bi<sub>2</sub>O<sub>3</sub> and quantifying its proportion within the material. Zeta potential measurements revealed values ranging from − 11.9 to − 14.2 mV (<i>p</i> &lt; 0.01) with increasing bismuth content. This may have influenced cell behavior, specifically adhesion. In vitro, three-times more osteoblasts adhere to 10Bi-BG surfaces than BG surfaces. Bioactivity, in terms of apatite formation ability, was verified in vitro through immersion in SBF. Finally, combining 10Bi-BG with radiation significantly induced greater cell death than radiation alone. The SER of 10Bi-BG was approximately 2.6. Consequently, bismuth-doped 58&#xa0;S bioglasses represent a promising bifunctional platform capable of simultaneously amplifying localized radiotherapy efficacy and stimulating bone tissue regeneration in the comprehensive management of bone malignancies.</p>

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Bismuth containing 58S bioglass amplifies radiation induced cell death and promotes bone regeneration

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月6日

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  • Yasser F. Ali,
  • Mahmoud A. Kenawy,
  • Ibrahim M. Hassan,
  • Hussein M. Abdelhafez,
  • Hany El Bahnasawy,
  • Amir Eissa

摘要

With the aim to improve local cancer radiotherapy while maintaining the tissue-regenerative properties of the glass, bioglasses with the composition (58 − x)SiO2–36CaO–6P2O5–xBi2O3 (where x = 0, 2, 5, or 10 wt%) were synthesized using the sol-gel method. The obtained glasses were labeled as BG, 2Bi-BG, 5Bi-BG, and 10Bi-BG, respectively. Numerous characterization techniques, including XRD, FTIR, SEM-EDX, and DLS were utilized. MTT, fluorescence microscopy, and flow cytometry were used to assess biocompatibility, osteointegration, and sensitization enhancement ratio (SER), respectively, after bismuth addition. A broad hump centered at 12° 2θ, indicating the amorphous, glassy nature of the products. Doped samples showed additional weak reflections confirming the presence of Bi2O3 and quantifying its proportion within the material. Zeta potential measurements revealed values ranging from − 11.9 to − 14.2 mV (p < 0.01) with increasing bismuth content. This may have influenced cell behavior, specifically adhesion. In vitro, three-times more osteoblasts adhere to 10Bi-BG surfaces than BG surfaces. Bioactivity, in terms of apatite formation ability, was verified in vitro through immersion in SBF. Finally, combining 10Bi-BG with radiation significantly induced greater cell death than radiation alone. The SER of 10Bi-BG was approximately 2.6. Consequently, bismuth-doped 58 S bioglasses represent a promising bifunctional platform capable of simultaneously amplifying localized radiotherapy efficacy and stimulating bone tissue regeneration in the comprehensive management of bone malignancies.