<p>Dental caries initiation involves enamel demineralization due to the loss of calcium and phosphate ions. Although traditional fluoride products are effective, they can have limitations and side effects. Consequently, remineralizing agents, such as hydroxyapatite doped with metal ions, have attracted attention. This study evaluated the remineralization efficacy of MCZn&amp;Mg-HA on demineralized enamel. After creating artificial carious lesions, dental samples were divided into three groups: A, B, and C. Each group was treated daily for 14 days. Microhardness was measured at baseline and on days 0, 3, 7, and 14 using a vickers hardness tester. Post-treatment surface morphology was examined by scanning electron microscopy (SEM). Data were analyzed using one-way ANOVA, followed by Tukey’s post hoc test for group comparisons. The study is designed as an in vitro, 14-day experiment. A graphical abstract would be most welcome for dental practitioners, providing a visual overview of the procedures, experimental parameters, and criteria, enabling readers to fully understand the experimental course and assess its reliability. MCZn&amp;Mg-HA significantly increased enamel microhardness compared with group C (<i>p</i> &lt; 0.05). The highest %SMHR was observed in group A, followed by group B. SEM images showed smooth, uniform surfaces in groups A and B, whereas group C exhibited porosity. Both MCZn&amp;Mg-HA and group A demonstrated remineralizing effects; however, group A showed greater remineralization potential and may be considered a promising non-fluoride alternative for enamel repair and protection.</p>

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Comparative remineralizing effects of mouthwashes containing zinc and magnesium-doped hydroxyapatite

  • Zahra Najaf Targhi,
  • Akbar Esmaeili,
  • Farhad Bakhshi

摘要

Dental caries initiation involves enamel demineralization due to the loss of calcium and phosphate ions. Although traditional fluoride products are effective, they can have limitations and side effects. Consequently, remineralizing agents, such as hydroxyapatite doped with metal ions, have attracted attention. This study evaluated the remineralization efficacy of MCZn&Mg-HA on demineralized enamel. After creating artificial carious lesions, dental samples were divided into three groups: A, B, and C. Each group was treated daily for 14 days. Microhardness was measured at baseline and on days 0, 3, 7, and 14 using a vickers hardness tester. Post-treatment surface morphology was examined by scanning electron microscopy (SEM). Data were analyzed using one-way ANOVA, followed by Tukey’s post hoc test for group comparisons. The study is designed as an in vitro, 14-day experiment. A graphical abstract would be most welcome for dental practitioners, providing a visual overview of the procedures, experimental parameters, and criteria, enabling readers to fully understand the experimental course and assess its reliability. MCZn&Mg-HA significantly increased enamel microhardness compared with group C (p < 0.05). The highest %SMHR was observed in group A, followed by group B. SEM images showed smooth, uniform surfaces in groups A and B, whereas group C exhibited porosity. Both MCZn&Mg-HA and group A demonstrated remineralizing effects; however, group A showed greater remineralization potential and may be considered a promising non-fluoride alternative for enamel repair and protection.