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<p>Layered double hydroxides (LDHs) are versatile materials with wide-ranging uses in catalysis, drug delivery, and antimicrobial systems due to their tunable layered structure. In this study, selenium (Se)-modified Al/Zn LDHs were developed to enhance bioactivity by utilizing Se’s strong antioxidant and antimicrobial properties. The LDHs were further functionalized with polycarbazole (PCz) at 0.2–1 wt% and characterized using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) with elemental mapping confirming successful incorporation of Se and PCz. Electrochemical studies showed that the polymer-coated LDH catalyst enables selective in-situ generation of hydrogen peroxide (H₂O₂) and sustained reactive oxygen species (ROS) production under physiological and mildly alkaline conditions. This tunable ROS activity indicates controllable antibacterial potential. Zone inhibition tests demonstrated that PCz-modified Se–LDH nanohybrids exhibited stronger antibacterial effects against <i>Bacillus subtilis</i> and <i>Escherichia coli</i> than unmodified samples, highlighting their promise as advanced, tunable antimicrobial materials for biomedical and environmental applications.</p>

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Selenium-polycarbazole modified LDHs: dual-mode antibacterial catalysts with tunable reactive oxygen species generation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月29日

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  • Mary Taylor,
  • Nijaye McGowan,
  • Morgan M. Callahan,
  • Cristian Rodriguez,
  • Audrey F. Adcock,
  • Rajeev Kumar,
  • Jayla Jenkins,
  • Liju Yang,
  • Ufana Riaz

摘要

Layered double hydroxides (LDHs) are versatile materials with wide-ranging uses in catalysis, drug delivery, and antimicrobial systems due to their tunable layered structure. In this study, selenium (Se)-modified Al/Zn LDHs were developed to enhance bioactivity by utilizing Se’s strong antioxidant and antimicrobial properties. The LDHs were further functionalized with polycarbazole (PCz) at 0.2–1 wt% and characterized using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) with elemental mapping confirming successful incorporation of Se and PCz. Electrochemical studies showed that the polymer-coated LDH catalyst enables selective in-situ generation of hydrogen peroxide (H₂O₂) and sustained reactive oxygen species (ROS) production under physiological and mildly alkaline conditions. This tunable ROS activity indicates controllable antibacterial potential. Zone inhibition tests demonstrated that PCz-modified Se–LDH nanohybrids exhibited stronger antibacterial effects against Bacillus subtilis and Escherichia coli than unmodified samples, highlighting their promise as advanced, tunable antimicrobial materials for biomedical and environmental applications.