<p>This study aimed to assess the effect of experimental cleaning agents on microshear bond strength (µSBS) of zirconia ceramic following saliva contamination. In this study 128 zirconia blocks (10 × 6 × 3&#xa0;mm) were fabricated, polished, sandblasted and divided in eight groups (<i>n</i> = 16). Except for the control (Group1), specimens were immersed in natural saliva for 1&#xa0;min, and either did not rinsed with water (Group2) and/or treated with solutions as follow after rinsing with water. The specimens were cleaned with experimental cleaning solutions containing activated carbon, zeolite and Zr(OH)₄ with a pH of 10 and 13 (Group3 and 4), experimental solutions containing activated carbon, zeolite, Na(OH), and ZrO₂ at a pH of 10 and 13 (Group5 and 6), Ivoclean solution (Group7), or water alone (Group8). The water contact angle was measured by a goniometer, and the elements on the zirconia surface were quantified by energy dispersive X-ray spectroscopy (EDS). G-Premio was applied on the blocks and composite cylinders were bonded to the surface. The µSBS was measured, and data were analyzed by one-way ANOVA and Tukey’s test. Saliva contamination significantly decreased the µSBS (<i>P</i> &lt; 0.001) and the lowest value was recorded in Group8. Group4 showed the highest µSBS and the lowest contact angle (<i>P</i> &lt; 0.001). Other solutions slightly increased the µSBS and decreased contact angle. EDS revealed that cleaning agents reduced contaminant elements especially in groups with high Ph. Application of experimental cleaning agents enhanced the µSBS to ceramic and decreased the contact angle of water.</p>