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<p>In this study, we developed titanium dioxide nanoparticles loaded with polyphenols from a hydroalcoholic extract of <i>Polygonum cuspidatum</i> (TiO<sub>2</sub>NPs-loaded EPc), and characterized their physicochemical properties, microstructure, and anticancer properties. The TiO<sub>2</sub>NPs-loaded EPc exhibited a spherical morphology with smooth surfaces and an average particle size from 23.2 to 25.4&#xa0;nm. In aqueous media, the particle size increased, reaching a mean hydrodynamic diameter of 298.8 and 461&#xa0;nm with a polydispersity index of 0.320 and 0.574 for TiO<sub>2</sub>NPs-loaded EPc R<sub>2:1</sub> and R<sub>1:1</sub>, respectively, as determined by dynamic light scattering (DLS) analysis. FT-IR and XRD analysis confirmed that incorporation of the ethanolic extract did not alter the functional groups or crystallinity of the TiO<sub>2</sub>NPs. The TiO<sub>2</sub>NPs-loaded EPc exhibited dose-dependent cytotoxicity against Caco-2 cells, with IC<sub>50</sub> values of 25.8 ± 6.1&#xa0;µg/ml and 34.3 ± 7.1&#xa0;µg/ml for TiO<sub>2</sub>NPs-loaded EPc R<sub>1:1</sub> and R<sub>2:1,</sub> respectively. These findings suggest that TiO<sub>2</sub>NPs have potential as carriers of bioactive compounds for anticancer treatment.</p>

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Titanium dioxide (TiO2) nanoparticles as carriers of Polygonum cuspidatum root hydroalcoholic extract: physicochemical, structural, and anticancer properties

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月16日

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  • Gabriela Fletes-Vargas,
  • Rogelio Rodríguez-Rodríguez,
  • Gabriel Luna-Bárcenas,
  • Oscar A. González-Vargas,
  • Alejandro Pérez-Larios,
  • Hugo Espinosa-Andrews

摘要

In this study, we developed titanium dioxide nanoparticles loaded with polyphenols from a hydroalcoholic extract of Polygonum cuspidatum (TiO2NPs-loaded EPc), and characterized their physicochemical properties, microstructure, and anticancer properties. The TiO2NPs-loaded EPc exhibited a spherical morphology with smooth surfaces and an average particle size from 23.2 to 25.4 nm. In aqueous media, the particle size increased, reaching a mean hydrodynamic diameter of 298.8 and 461 nm with a polydispersity index of 0.320 and 0.574 for TiO2NPs-loaded EPc R2:1 and R1:1, respectively, as determined by dynamic light scattering (DLS) analysis. FT-IR and XRD analysis confirmed that incorporation of the ethanolic extract did not alter the functional groups or crystallinity of the TiO2NPs. The TiO2NPs-loaded EPc exhibited dose-dependent cytotoxicity against Caco-2 cells, with IC50 values of 25.8 ± 6.1 µg/ml and 34.3 ± 7.1 µg/ml for TiO2NPs-loaded EPc R1:1 and R2:1, respectively. These findings suggest that TiO2NPs have potential as carriers of bioactive compounds for anticancer treatment.