Scholarlink

<p>Aggregation-induced emission (AIE)-active fluorescent probes have emerged as promising tools for in vivo biomarker detection and biological imaging due to their unconventional emission behavior in aggregated state. In this study, we designed novel imidazole-based aggregation-induced emission luminogens (AIEgens), TPIT, featuring a symmetrical donor-π-bridge-acceptor-π-bridge-donor (D-π-A-π-D) backbone. By introducing benzothiadiazole (BT)-derived acceptors with different electron-withdrawing capabilities and steric hindrance, a series of AIEgens (TPIT-B, TPIT-P, TPIT-N) were successfully synthesized, exhibiting tunable emission windows from red (641&#xa0;nm) to near-infrared (NIR) region (802&#xa0;nm), typical AIE characteristics, significant Stokes shifts (&gt; 120&#xa0;nm ) and remarkable reactive oxygen species (ROS) generation efficiency. In further animal experiments, TPIT-N nanoparticles (NPs) achieved high-contrast NIR imaging of osteosarcoma (OS) tissues. Our preliminary findings reveal that the optical performance of TPIT can be facilely modulated to meet specific requirements by rational selection of acceptor cores. This flexible molecular engineering strategy endows TPIT with board potential in medical diagnostics, tumor treatments and other biological applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Emission-tunable aromatic thiadiazole derivatives based on triphenylimidazole with aggregation-induced emission activity and their application in osteosarcoma imaging

  • 期刊论文

  • 发表日期：

    2026年7月7日

查看全文
  • Chen Zhang,
  • Jun Wang

摘要

Aggregation-induced emission (AIE)-active fluorescent probes have emerged as promising tools for in vivo biomarker detection and biological imaging due to their unconventional emission behavior in aggregated state. In this study, we designed novel imidazole-based aggregation-induced emission luminogens (AIEgens), TPIT, featuring a symmetrical donor-π-bridge-acceptor-π-bridge-donor (D-π-A-π-D) backbone. By introducing benzothiadiazole (BT)-derived acceptors with different electron-withdrawing capabilities and steric hindrance, a series of AIEgens (TPIT-B, TPIT-P, TPIT-N) were successfully synthesized, exhibiting tunable emission windows from red (641 nm) to near-infrared (NIR) region (802 nm), typical AIE characteristics, significant Stokes shifts (> 120 nm ) and remarkable reactive oxygen species (ROS) generation efficiency. In further animal experiments, TPIT-N nanoparticles (NPs) achieved high-contrast NIR imaging of osteosarcoma (OS) tissues. Our preliminary findings reveal that the optical performance of TPIT can be facilely modulated to meet specific requirements by rational selection of acceptor cores. This flexible molecular engineering strategy endows TPIT with board potential in medical diagnostics, tumor treatments and other biological applications.