Scholarlink

<p>The novel series of 3-acetyl phenylthiazolidine-4-carboxyamide derivatives were prepared, structurally characterized by FTIR, <sup>1</sup>H and <sup>13</sup>C-NMR, and mass spectrometry, and described for their possible applications against prostate cancer cells. These amide thiazolidines include many substituents on a phenyl ring, such as 3-NO<sub>2</sub>, 3,4,5-tri-OCH<sub>3</sub>, 4-COCH<sub>3</sub>, 3,4-di-OCH<sub>3</sub>, benzoyl, and diphenyl. Biological activity assays applying the MTT assay for PC3 cells were shown to evaluate the bioactivity of these thiazolidines. The amide thiazolidines revealed promising cytotoxic amide thiazolidines <b>TAM1</b> (IC<sub>50</sub> = 75.95 µg/ml) and <b>TAM2</b> (IC<sub>50</sub> = 79.82 µg/ml) displayed notable strength against PC3 cells. The molecular docking against DNA gyrase, two types of proteins (1SJO and 4HJO), and enzymes exposed strong binding interactions of an examined molecule inside their active sites, making them valuable applicants for further development as therapeutic agents against the human prostate cancer cell line (PC3). Strong total first hyperpolarizability <i>β</i><sub>tot</sub> up to 2766.67 a.u. has been achieved for <b>TAM1</b>. The direct correlation was attained between the total hyperpolarizability <i>β</i><sub>tot</sub> and<i> E</i><sub>g</sub> (energy gap) and between a <i>β</i><sub>HRS</sub> and <i>β</i><sub>//</sub>. This study will offer additional knowledge regarding exploring novel thiazolidines, revealing promising, cytotoxic, and nonlinear optical thiazolidines, and progressing in technologies that manipulate and control light for various purposes, such as optical signal processing, photorefractive devices, and photonics.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Antitumor, biological and nonlinear optical activities of novel thiazolidines

  • 期刊论文

  • 发表日期：

    2025年10月27日

查看全文
  • Sabah Abbas,
  • Ahmed A. Majed,
  • Mostafa Hashim Moker,
  • Tahseen A. Alsalim,
  • Toufik Bensafi,
  • Djebar Hadji,
  • Benamar Baroudi,
  • Ahmed Adnan Al-Khafagi,
  • Dawood S. Abid

摘要

The novel series of 3-acetyl phenylthiazolidine-4-carboxyamide derivatives were prepared, structurally characterized by FTIR, 1H and 13C-NMR, and mass spectrometry, and described for their possible applications against prostate cancer cells. These amide thiazolidines include many substituents on a phenyl ring, such as 3-NO2, 3,4,5-tri-OCH3, 4-COCH3, 3,4-di-OCH3, benzoyl, and diphenyl. Biological activity assays applying the MTT assay for PC3 cells were shown to evaluate the bioactivity of these thiazolidines. The amide thiazolidines revealed promising cytotoxic amide thiazolidines TAM1 (IC50 = 75.95 µg/ml) and TAM2 (IC50 = 79.82 µg/ml) displayed notable strength against PC3 cells. The molecular docking against DNA gyrase, two types of proteins (1SJO and 4HJO), and enzymes exposed strong binding interactions of an examined molecule inside their active sites, making them valuable applicants for further development as therapeutic agents against the human prostate cancer cell line (PC3). Strong total first hyperpolarizability βtot up to 2766.67 a.u. has been achieved for TAM1. The direct correlation was attained between the total hyperpolarizability βtot and Eg (energy gap) and between a βHRS and β//. This study will offer additional knowledge regarding exploring novel thiazolidines, revealing promising, cytotoxic, and nonlinear optical thiazolidines, and progressing in technologies that manipulate and control light for various purposes, such as optical signal processing, photorefractive devices, and photonics.