Scholarlink

<p>This study aimed to investigate photobiomodulation (PBM) by infrared LED lights as a non-invasive treatment for respiratory distress syndrome in premature and mature newborns, utilizing mature human lung epithelial alveolar cells as a model system. Human lung epithelial alveolar cells were irradiated using liquid-cooled infrared LED setups. Experiments were conducted with three wavelengths (660, 830, 940&#xa0;nm), two light powers (30, 60&#xa0;mW), and four energy levels (3, 5, 10, 15&#xa0;J/cm<sup>2</sup>), with exposures at 24, 48, and 72&#xa0;h. Each experiment was repeated three times. Statistical analysis was performed using one-way ANOVA via GraphPad Prism software, with <i>p</i> &lt; 0.05 considered significant. PBM significantly increased surfactant protein levels. Specifically, 660 and 830&#xa0;nm wavelengths led to over a 50% increase in Surfactant Protein A. Combined 830 and 940&#xa0;nm irradiation resulted in up to a 150% increase in Surfactant Protein B. PBM at 830&#xa0;nm increased Surfactant Protein C by nearly 40%. Furthermore, 830&#xa0;nm and particularly 940&#xa0;nm irradiations caused approximately a 120% increase in Surfactant Protein D. Photobiomodulation therapy using infrared lights enhanced surfactant protein production in mature human lung epithelial alveolar cells. These findings suggest that this applied method may be a promising non-invasive treatment for respiratory distress syndrome in newborns, addressing a critical gap in current research.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of photobiomodulation therapy on surfactant production increase in human lung epithelial alveolar cells

  • 期刊论文

  • 发表日期：

    2025年9月25日

查看全文
  • Halil İbrahim Özdemir,
  • Metin Bilge,
  • Ertuğrul Özkan,
  • Nur Selvi Günel,
  • Hatice Elif Özdemir,
  • Ayshan Ahadova,
  • Ayşe Çekin,
  • Latife Merve Oktay Çelebi,
  • Çağla Kayabaşı,
  • Züleyha Özçelik Çetinel,
  • Duygu Bilge,
  • Murat Koylu,
  • Cansın Şirin Tomruk,
  • Canberk Tomruk,
  • Şenay Şanlıer,
  • Demet Terek,
  • Elif Erol,
  • Fahri Emrah Soylu,
  • Mehmet Yalaz,
  • İsmail Oran,
  • Cumhur Gündüz

摘要

This study aimed to investigate photobiomodulation (PBM) by infrared LED lights as a non-invasive treatment for respiratory distress syndrome in premature and mature newborns, utilizing mature human lung epithelial alveolar cells as a model system. Human lung epithelial alveolar cells were irradiated using liquid-cooled infrared LED setups. Experiments were conducted with three wavelengths (660, 830, 940 nm), two light powers (30, 60 mW), and four energy levels (3, 5, 10, 15 J/cm2), with exposures at 24, 48, and 72 h. Each experiment was repeated three times. Statistical analysis was performed using one-way ANOVA via GraphPad Prism software, with p < 0.05 considered significant. PBM significantly increased surfactant protein levels. Specifically, 660 and 830 nm wavelengths led to over a 50% increase in Surfactant Protein A. Combined 830 and 940 nm irradiation resulted in up to a 150% increase in Surfactant Protein B. PBM at 830 nm increased Surfactant Protein C by nearly 40%. Furthermore, 830 nm and particularly 940 nm irradiations caused approximately a 120% increase in Surfactant Protein D. Photobiomodulation therapy using infrared lights enhanced surfactant protein production in mature human lung epithelial alveolar cells. These findings suggest that this applied method may be a promising non-invasive treatment for respiratory distress syndrome in newborns, addressing a critical gap in current research.