<p>This study assessed the knowledge and practices of sweetpotato farmers in integrated nutrient management in four districts of the Central Region of Ghana. Descriptive cross-sectional survey approach was adopted for the study. One hundred and twenty sweetpotato farmers were purposively sampled. Majority of the farmers were males (72.5%) with about two-thirds ranging between the ages of 40–50 with considerable years of experience in sweetpotato production. A greater proportion of the participants are smallholder farmers (95.8%) managing small parcels of land ≤ 2&#xa0;ha. Although a greater percentage (86.7) of the farmers reported no decline in yields over the years, 62.5% of the few who observed decline attributed it to low rainfall amounts while 37.5% indicated loss of nutrients through continuous cropping. Majority (91.7%) of the participants did not improve the fertility of their lands. A majority (73.3%) of the participants perceived organic nutrient sources as better option for crop production. The results further revealed that majority of farmers (85%) did not perceive that the application of fertilizer influences the taste of sweetpotato. The 15% of farmers who thought fertilizer use affected taste alluded it to watery tubers. The farmers singled out NPK as the type of fertilizer that affects the keeping quality of tubers. A multivariable analysis further showed that land preparation methods, perceptions of biochar as amendment, beliefs about fertilizer type, and perceived nutrient quality were significantly associated with fertilizer use. Farmers who ploughed and constructed mounds were markedly less likely to apply organic or mineral fertilizers (aOR = 0.012). The study highlights the importance of considering farmers’ perceptions, knowledge and practices when designing soil fertility interventions and calls for farmer education in integrated nutrient management to boost yields.</p>