<p>Climate is rapidly changing, and extreme weather events are more likely common. This alerts to deal with climate-related shocks and escalate resilience. Yet, research on farm households’ resilience and factors influencing their resilience capacity are limited. This study aimed to estimate the resilience capacity of farm households across agrological zones and evaluate factors influencing resilience capacity to climate change-induced shocks in Tigray, Ethiopia. The climate resilience index was estimated based on resilience capacities using an agro-ecological unit of analysis. Beta regression and multivariate and Shiny Resilience Index measurement and analysis models were applied. The result shows that the average climate resilience index of the farm households is 0.383, which is below the minimum threshold, and are highly vulnerable to climate change-induced shocks. It revealed that male-headed households and farm households residing in midland agro-ecology are relatively more resilient. The absorptive capacity is highest contributor for better resilience capacity, followed by the adaptive capacity. Stability and being better off in income, food access, and asset holding are important components for better resilience. However, low access to basic services, limited early warning systems, and inadequate adaptive capacity were profound causes for low resilience capacity. The study suggests that interventions should focus primarily on absorptive capacities to boost the resilience of farm households. Likewise, efforts towards increased resilience should target the least resilient farm households and agro-ecology to realize the climate change resilient food systems. Scale up agro-ecology-based climate change responses, such as irrigation, agroforestry, crop diversity, dietary change, and organic fertilizer are important to build resilience.</p>