<p>This paper examines the role of Ghanaian traditional knowledge in promoting sustainable development through the use and care of indigenous textiles. A qualitative cross-sectional design was adopted to uncover how traditional knowledge and the principles of circular economy inform sustainable textile practices. The purposive sampling technique was used to collect data via face-to-face interview with fifteen (15) middle-aged and older adults in Accra, Ghana. Data was analysed using thematic analysis. It was identified that: draping fabric as a means of body covering; prescribed attire for traditional occasions; collaborative apparel consumption; apparel repair culture; and practising appropriate laundry techniques were key traditional knowledge contributors to sustainable use and care of traditional textiles among Ghanaians. These textile practices were also found to support the tenets of circular economy. The study’s findings highlight the significance of traditional knowledge and indigenous textile consumption behaviours as tools for sustainable development. It is recommended that these practices be preserved, adapted, and integrated into contemporary sustainability efforts, in order to promote value maintenance of textile materials and ensure that the components of textile products are not completely lost through unsustainable use and care practices.</p>