<p>Renewable nano-materials have become extremely advantageous for sustainability, the circular economy, and cleaner production practices. This work emphasizes the importance of developing a methodological approach for selecting nano-cellulosic composite materials. It also presents a material selection system framework with an interactive computer environment to enhance a more sustainable circular economy, thereby developing more functional green bio-products. The presented interactive computer selection system framework requirements including identifying the desirable characteristics of nano-cellulosic materials, data communication interface, and interactive design requirement integrated with a multi-criterion decision-making (MCDM) model. The significance of establishing a proper knowledge-based system for the nano-cellulosic composite materials was also presented, where several knowledge-based selection steps and features were properly defined. This was achieved by using a database and MCDM interface that ranks the available constituent alternatives for the designer. This new systematic approach for selecting renewable nano-cellulosic composite materials would create a backbone guideline for the designers, improve sustainable socio-economic design options for bio-products, support the development of ecosystems, and speed up the design process of bio-products to enhance the circular economy and sustainability.</p>