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Purpose of Review <p>Cardiovascular diseases (CVDs) are the leading cause (32%) of global morbidomortalities. Understanding how dietary interventions influence molecular pathways offers practical, preventive solutions for reducing this burden. Additionally, this topic targets a wide range of stakeholders, including researchers, healthcare professionals, and the public seeking strategies to ensure healthy hearts.</p> Recent Findings <p>From 2023 to 2030, the market of functional foods and nutraceuticals is expected to see a growth of 7.5% CAGR that indicates increasing public and scientific interest in health-promoting diets. It has been estimated that balanced diets like the Mediterranean or traditional Brazilian diets can reduce the global CVD deaths by 20%.</p> Summary <p>Diet therapies are significant in mitigating cardiovascular risk factors and enhancing heart health. The bioactive compounds in various cardioprotective foods modulate molecular pathways associated with inflammation, oxidative stress, and lipid metabolism. These mechanisms mostly converge on key pathways like Nitric oxide, NF-κB, Nrf2/ARE, PI3K/Akt, mitochondria regulatory, and epigenetic pathways. We utilized molecular docking techniques and found significant interactions between the bioactive compounds like Epicatechin, Resveratrol, Quercetin, and Curcumin found in cardioprotective foods particularly with the key proteins involved in Nitric oxide signaling. Our study supports the cardioprotective implications of traditional dietary recommendations by highlighting how bioactive compounds act at the cellular and molecular levels.</p> Graphical Abstract <p></p>

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Cardioprotective Foods: A Molecular Perspective on Pathways and Mechanisms

  • 期刊论文

  • 发表日期：

    2025年5月9日

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  • Ghulam Mehdi Dar,
  • Amanpreet Kaur,
  • Parameswar Sahu,
  • Vishal Batra,
  • Bhawna Mahajan,
  • Mohammad Mahfuzul Haque,
  • Sundeep Singh Saluja

摘要

Purpose of Review

Cardiovascular diseases (CVDs) are the leading cause (32%) of global morbidomortalities. Understanding how dietary interventions influence molecular pathways offers practical, preventive solutions for reducing this burden. Additionally, this topic targets a wide range of stakeholders, including researchers, healthcare professionals, and the public seeking strategies to ensure healthy hearts.

Recent Findings

From 2023 to 2030, the market of functional foods and nutraceuticals is expected to see a growth of 7.5% CAGR that indicates increasing public and scientific interest in health-promoting diets. It has been estimated that balanced diets like the Mediterranean or traditional Brazilian diets can reduce the global CVD deaths by 20%.

Summary

Diet therapies are significant in mitigating cardiovascular risk factors and enhancing heart health. The bioactive compounds in various cardioprotective foods modulate molecular pathways associated with inflammation, oxidative stress, and lipid metabolism. These mechanisms mostly converge on key pathways like Nitric oxide, NF-κB, Nrf2/ARE, PI3K/Akt, mitochondria regulatory, and epigenetic pathways. We utilized molecular docking techniques and found significant interactions between the bioactive compounds like Epicatechin, Resveratrol, Quercetin, and Curcumin found in cardioprotective foods particularly with the key proteins involved in Nitric oxide signaling. Our study supports the cardioprotective implications of traditional dietary recommendations by highlighting how bioactive compounds act at the cellular and molecular levels.

Graphical Abstract