<p>Negative social exchange has been the primary framework for understanding negative interactions in social relationships that adversely affect health and well-being. Using classic content analysis, this study explores whether inquiries about interpersonal stress within one’s relationships elicit descriptions of negative social exchange and whether the types of stressful experiences reported by young and middle-aged adults (<i>N</i> = 298) reflect the negative social exchange categories depicted in previous research. The current study furthers our understanding of the composition of these adults’ negative social exchange networks and describes interpersonal stressors across close and peripheral relationships. Our analysis indicates that among young and middle-aged adults, a large portion of negative social exchange was associated with close relationships and included experiencing misdeeds and violation of relationship norms, misdirected control and undermining, rejection and neglect, and failed social support. Among responses categorized as “others,” stressors were associated with personal relationships, work, third parties, school, children, and health.</p>