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Background <p>Cyclophosphamide (CPA), a globally used chemotherapeutic and immunosuppressive drug, is associated with several adverse effects and reproductive dysfunction, including erectile dysfunction. Shilajit, a revered traditional Ayurvedic medicine, possesses antioxidant, aphrodisiac, rejuvenating, and anticancer properties, suggesting its therapeutic potential against CPA induced erectile dysfunction.</p> Objective <p>The present study aimed to evaluate the ameliorative potential of Shilajit supplementation against CPA induced erectile dysfunction.</p> Methodology <p>Adult male Parkes mice received a single IP injection of CPA (200&#xa0;mg/kg body weight) on day one, followed by oral supplementation of Shilajit (100 or 200&#xa0;mg/kg body weight) daily for 35&#xa0;days.</p> Results <p>CPA exposure induced marked structural alterations in the corpus cavernosum, including loss of smooth muscles, increased collagen deposition, oxidative stress, and reduced nitric oxide (NO) bioavailability. CPA also disrupted the HPG axis, leading to decreased testosterone levels and impaired libido. Shilajit supplementation significantly restored penile histoarchitecture by improving the SM/Collagen ratio. It also ameliorated NO production through upregulation of eNOS and nNOS and suppressing PDE5α, along with concomitant improvements in cGMP and pAkt levels. Furthermore, Shilajit restored dopamine and serotonin levels along with elevated LH, FSH, and testosterone concentrations, thereby improving sexual behaviour and fertility potential. These ameliorative effects of Shilajit were associated with enhanced antioxidant defence, evidenced by increased SOD and catalase activities.</p> Conclusion <p>Shilajit ameliorates CPA-induced erectile dysfunction by reducing oxidative stress, restoring NO bioavailability, and activating the NO/cGMP signalling pathway, thereby improving endothelial function and penile erection.</p>

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Shilajit mitigates chemotherapeutic drug-induced erectile dysfunction via modulating HPG axis and NO/PDE5α signalling pathway

  • 期刊论文

  • 发表日期：

    2026年7月29日

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  • Arti Rajpoot,
  • Raghav Kumar Mishra

摘要

Background

Cyclophosphamide (CPA), a globally used chemotherapeutic and immunosuppressive drug, is associated with several adverse effects and reproductive dysfunction, including erectile dysfunction. Shilajit, a revered traditional Ayurvedic medicine, possesses antioxidant, aphrodisiac, rejuvenating, and anticancer properties, suggesting its therapeutic potential against CPA induced erectile dysfunction.

Objective

The present study aimed to evaluate the ameliorative potential of Shilajit supplementation against CPA induced erectile dysfunction.

Methodology

Adult male Parkes mice received a single IP injection of CPA (200 mg/kg body weight) on day one, followed by oral supplementation of Shilajit (100 or 200 mg/kg body weight) daily for 35 days.

Results

CPA exposure induced marked structural alterations in the corpus cavernosum, including loss of smooth muscles, increased collagen deposition, oxidative stress, and reduced nitric oxide (NO) bioavailability. CPA also disrupted the HPG axis, leading to decreased testosterone levels and impaired libido. Shilajit supplementation significantly restored penile histoarchitecture by improving the SM/Collagen ratio. It also ameliorated NO production through upregulation of eNOS and nNOS and suppressing PDE5α, along with concomitant improvements in cGMP and pAkt levels. Furthermore, Shilajit restored dopamine and serotonin levels along with elevated LH, FSH, and testosterone concentrations, thereby improving sexual behaviour and fertility potential. These ameliorative effects of Shilajit were associated with enhanced antioxidant defence, evidenced by increased SOD and catalase activities.

Conclusion

Shilajit ameliorates CPA-induced erectile dysfunction by reducing oxidative stress, restoring NO bioavailability, and activating the NO/cGMP signalling pathway, thereby improving endothelial function and penile erection.