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<p>Female reproductive health is influenced by a number of factors including inflammation. This study aimed to investigate the relationship between inflammatory markers and infertility, and to explore the association between inflammatory status and pregnancy outcomes among infertile women. This study included 166 women who were undergoing in vitro fertilization /intracytoplasmic sperm injection (IVF/ICSI). The participants were divided according to cause of infertility into: control group (<i>n</i> = 56), patients with polycystic ovary syndrome (<i>n</i> = 53), and patients with low AMH level (<i>n</i> = 57). Four inflammatory markers were calculated from complete blood count (CBC); neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) and their association with pregnancy outcomes by dividing into sub-groups, pregnant and non-pregnant. The mean levels of SIRI, SII, and NLR of PCOS group showed significant increase when compared to the control and low AMH groups. In contrast, PLR did not show a significant difference between the groups. Also, the mean levels of SIRI, SII, and NLR showed non -significant variations when compared among pregnant and non-pregnant subgroups in each type of infertility. While PLR showed significant increase in non-pregnant subgroup compared to pregnant subgroup of PCOS group. In conclusion; the current study found higher PLR, NLR, SII, and SIRI levels in PCOS patients compared to low AMH and control groups, implying that systemic inflammation may play a role in PCOS pathophysiology. However, no significant variations in inflammatory markers (excluding PLR) were found between pregnant and non-pregnant women for either type of infertility.</p>

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Association between some inflammatory biomarkers and in vitro fertilization success in women with infertility

  • 期刊论文

  • 发表日期：

    2026年7月7日

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  • Muhja Abdul Kareem Ahmed,
  • Shatha Abdul Wadood

摘要

Female reproductive health is influenced by a number of factors including inflammation. This study aimed to investigate the relationship between inflammatory markers and infertility, and to explore the association between inflammatory status and pregnancy outcomes among infertile women. This study included 166 women who were undergoing in vitro fertilization /intracytoplasmic sperm injection (IVF/ICSI). The participants were divided according to cause of infertility into: control group (n = 56), patients with polycystic ovary syndrome (n = 53), and patients with low AMH level (n = 57). Four inflammatory markers were calculated from complete blood count (CBC); neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) and their association with pregnancy outcomes by dividing into sub-groups, pregnant and non-pregnant. The mean levels of SIRI, SII, and NLR of PCOS group showed significant increase when compared to the control and low AMH groups. In contrast, PLR did not show a significant difference between the groups. Also, the mean levels of SIRI, SII, and NLR showed non -significant variations when compared among pregnant and non-pregnant subgroups in each type of infertility. While PLR showed significant increase in non-pregnant subgroup compared to pregnant subgroup of PCOS group. In conclusion; the current study found higher PLR, NLR, SII, and SIRI levels in PCOS patients compared to low AMH and control groups, implying that systemic inflammation may play a role in PCOS pathophysiology. However, no significant variations in inflammatory markers (excluding PLR) were found between pregnant and non-pregnant women for either type of infertility.