<p><?tk 4?>This study investigated the feasibility of customizing Eudragit EPO granules for Selective Laser Sintering (SLS) 3D printing. Owing to its fine particle size and cohesive nature, it showed poor flowability following hindering printability. Wet granulation technique was employed for improved micromeritic features. <i>In vitro</i> physico-technological and dissolution profile of the printed tablets were evaluated. The sintered tablets had accurate physical dimensions achieving the adequate mechanical strength for handling and transportation. Scanning electron microscopy (SEM) investigation confirmed successful sintering with low porosity, while dissolution profiles was shown the immediate drug release. These studies demonstrated the usefulness of tailored Eudragit EPO granules in producing high-quality, immediate-release, patient-specific tablets with SLS 3DP technology. This study lays the base for using SLS 3D printing to create personalized solid oral dosage forms. Future endeavors could focus on integrating different active pharmaceutical ingredient into optimized granules and researching alternative polymers to increase printability and tablet efficacy. Assessing <i>in vivo</i> behavior and meeting regulatory requirements will be critical steps toward clinical implementation, making this method a possible path for tailored drug delivery.</p> Graphical abstract <p></p>