<p>Silver nanoparticles, out of all the metal nanoparticles, are being researched for their outstanding antimicrobial activities. The main aim of this paper is to prepare a comprehensive review of different medicinal plants that are used to prepare silver nanoparticles, which can exert synergistic antibacterial activity against multidrug-resistant pathogenic microorganisms. Many studies are conducted on metal nanoparticles because of their unique electrical, catalytic, and optical characteristics. The exploitation of plants to synthesize metal nanoparticles has arisen as an alternate option to overcome the restrictions of traditional synthesis techniques, including chemical and physical methods. Biomolecules, including flavonoids, enzymes, terpenoids, and amino acids/proteins, derived from various plant extracts, have been employed as reducing and stabilizing agents in preparing silver nanoparticles (AgNPs). Researchers are encountering a substantial obstacle in creating stable and precisely shaped AgNPs. Over the twenty years, there have been multiple attempts to create methods for synthesizing AgNPs using plants. The goal is to manufacture AgNPs that are stable, affordable, and environmentally benign. Numerous researches published in the last twenty years have described more than a hundred distinct plant extract sources for producing AgNPs. Most of the reviews were focused on numerous plant sources for the production of AgNPs, various characterization approaches for the characterization of AgNPs, and antibacterial efficacy against bacteria. Although there is much research on the plant-mediated preparation of AgNPs and the antibacterial activity of AgNPs, this is the first review paper mostly focused on methods, formulation, and factors influencing the synthesis of silver nanoparticles. Apart from this, this review presents different medicinal plants used to synthesize AgNPs, which produce synergistic antibacterial activity against multidrug-resistant pathogenic microorganisms.</p>