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<p>The genus Curcuma is economically important due to its culinary and medicinal uses, and its rhizome extracts have been used recently for their antibacterial, anti-diabetic, anti-oxidant, anti-inflammatory, anti-cancer, anti-allergic, and wound-healing properties. The chloroplast of Maturase K protein (Mat K gene), which is 1500&#xa0;bp long and located in the intron of the chloroplast trn K gene, is highly conserved and contributes to group II intron splicing. <i>Curcuma</i>, a member of Zingiberaceae, contains more than 100 species; most of these species’ physicochemical properties of the Maturase K gene are not characterized. In the current study, physicochemical characteristics such as isoelectric points, aliphatic index, instability index, molecular weight, Hydropathicity, phylogenetic analysis, and protein modeling of ten sequences of Maturase K protein from <i>Curcuma</i> species were found through Insilico approaches. Physicochemical properties were found using the Expasy ProtParam server, sequence alignment was done through MEGA ClustalW, secondary and tertiary structures were predicted through the pyre2 server while the phylogenetic tree was constructed through MEGA software. It was observed that Maturase K protein in some species of Curcuma had hydrophilic character while some have hydrophobic. They show a wide variety in their molecular weight, aliphatic index, instability index, and isoelectric points. Phylogenetic study demonstrated polyphyletic origin with a restricted genetic basis. The tertiary structures of proteins are better understood thanks to the produced 3D models.</p>

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In silico study of Maturase K protein in different Curcuma species and their phylogenetic analysis

  • 期刊论文

  • 发表日期：

    2025年9月15日

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  • Ayesha Khan,
  • Hajra Ayaz,
  • Hafsa Ayaz,
  • Salman Khan,
  • Sana Bibi,
  • Khalil Ur Rahman,
  • Sana Nasser,
  • Shah Fahad,
  • Hazart Hussain,
  • Mehdi Rahimi

摘要

The genus Curcuma is economically important due to its culinary and medicinal uses, and its rhizome extracts have been used recently for their antibacterial, anti-diabetic, anti-oxidant, anti-inflammatory, anti-cancer, anti-allergic, and wound-healing properties. The chloroplast of Maturase K protein (Mat K gene), which is 1500 bp long and located in the intron of the chloroplast trn K gene, is highly conserved and contributes to group II intron splicing. Curcuma, a member of Zingiberaceae, contains more than 100 species; most of these species’ physicochemical properties of the Maturase K gene are not characterized. In the current study, physicochemical characteristics such as isoelectric points, aliphatic index, instability index, molecular weight, Hydropathicity, phylogenetic analysis, and protein modeling of ten sequences of Maturase K protein from Curcuma species were found through Insilico approaches. Physicochemical properties were found using the Expasy ProtParam server, sequence alignment was done through MEGA ClustalW, secondary and tertiary structures were predicted through the pyre2 server while the phylogenetic tree was constructed through MEGA software. It was observed that Maturase K protein in some species of Curcuma had hydrophilic character while some have hydrophobic. They show a wide variety in their molecular weight, aliphatic index, instability index, and isoelectric points. Phylogenetic study demonstrated polyphyletic origin with a restricted genetic basis. The tertiary structures of proteins are better understood thanks to the produced 3D models.