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<p>This study evaluates the larvicidal efficacy of an andrograpanin formulation against two vector mosquito species, <i>Aedes aegypti</i> and <i>Culex quinquefasciatus</i>. The active compound, andrograpanin, was isolated from fraction 4 of the methanol extract of the leaves of <i>Andrographis paniculata</i> (family: Acanthaceae), a well-known medicinal plant traditionally used in Ayurvedic and Chinese medicine for its anti-inflammatory, antibacterial, and antiviral properties. Recognized for its diverse bioactive compounds, <i>A. paniculata</i> has recently gained attention for its pesticidal potential. In this study, andrograpanin was formulated in mineral oil and tested at concentrations of 0.5, 1.0, 1.5, and 2.0&#xa0;ppm under laboratory conditions. The larvicidal activity was compared to an azadirachtin-based formulation as a positive control. Results showed that andrograpanin exhibited significant larvicidal effects, with LC₅₀ and LC₉₀ values for <i>Aedes aegypti</i> at 1.27&#xa0;ppm and 3.35&#xa0;ppm, respectively, and for <i>Culex quinquefasciatus</i> at 1.26&#xa0;ppm and 3.03&#xa0;ppm. The azadirachtin formulation demonstrated greater potency with lower LC₅₀ and LC₉₀ values. This study underscores the potential of andrograpanin-based formulations as eco-friendly alternatives to synthetic pesticides for controlling mosquito-borne diseases.</p>

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Evaluation of larvicidal efficacy of Andrograpanin formulation against mosquito vectors

  • 期刊论文

  • 发表日期：

    2025年5月31日

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  • Jelin Vilvest,
  • M. C. John Milton,
  • Alex Yagoo

摘要

This study evaluates the larvicidal efficacy of an andrograpanin formulation against two vector mosquito species, Aedes aegypti and Culex quinquefasciatus. The active compound, andrograpanin, was isolated from fraction 4 of the methanol extract of the leaves of Andrographis paniculata (family: Acanthaceae), a well-known medicinal plant traditionally used in Ayurvedic and Chinese medicine for its anti-inflammatory, antibacterial, and antiviral properties. Recognized for its diverse bioactive compounds, A. paniculata has recently gained attention for its pesticidal potential. In this study, andrograpanin was formulated in mineral oil and tested at concentrations of 0.5, 1.0, 1.5, and 2.0 ppm under laboratory conditions. The larvicidal activity was compared to an azadirachtin-based formulation as a positive control. Results showed that andrograpanin exhibited significant larvicidal effects, with LC₅₀ and LC₉₀ values for Aedes aegypti at 1.27 ppm and 3.35 ppm, respectively, and for Culex quinquefasciatus at 1.26 ppm and 3.03 ppm. The azadirachtin formulation demonstrated greater potency with lower LC₅₀ and LC₉₀ values. This study underscores the potential of andrograpanin-based formulations as eco-friendly alternatives to synthetic pesticides for controlling mosquito-borne diseases.