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<p><i>Picrorhiza kurroa</i> plantation varies from subalpine to alpine ranges 3000-5300&#xa0;m (msl) observed extensively across North Western to North Eastern Himalaya. International Union for Conservation of Nature and Natural Resources (IUCN) has already listed <i>P. kurroa</i> and related species under endangered flora. Bioactive leads, primarily two major principle(s) picroside I and picroside II besides many others, are derived from metabolic pathways especially in the underground roots cum rhizomes after 3–4&#xa0;years growth of this plant. Bioactive principles have been validated to revive vital function as evident from large demand in local markets. The growing demand for plant derived chemicals as such in various pharmaceutical industries has threatened the survival of many such endangered plant species. Researchers are developing alternatives for large scale production protocols from laboratory scale, medium scale, large scale and commercial scale production of such bioactive metabolites. <i>Agrobacterium rhizogenes</i> (<i>Rhizobium rhizogenes</i>) are virulent strains that often develop hairy roots. In vitro protocols are quite effective while growing co-cultivated explants to develop hairy roots. Since hairy roots potential for bioactive principles has been well documented, therefore, this particular review aims to highlight recent progress emphasizing feasibility and further potential applications in developing commodities for local and global markets.</p>

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Picrorhiza kurroa Royle ex Benth: potential of hairy root cultures for bioactive metabolic principles

  • 期刊论文

  • 发表日期：

    2025年4月29日

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  • Bhawna Pandey,
  • A. K. Gaur

摘要

Picrorhiza kurroa plantation varies from subalpine to alpine ranges 3000-5300 m (msl) observed extensively across North Western to North Eastern Himalaya. International Union for Conservation of Nature and Natural Resources (IUCN) has already listed P. kurroa and related species under endangered flora. Bioactive leads, primarily two major principle(s) picroside I and picroside II besides many others, are derived from metabolic pathways especially in the underground roots cum rhizomes after 3–4 years growth of this plant. Bioactive principles have been validated to revive vital function as evident from large demand in local markets. The growing demand for plant derived chemicals as such in various pharmaceutical industries has threatened the survival of many such endangered plant species. Researchers are developing alternatives for large scale production protocols from laboratory scale, medium scale, large scale and commercial scale production of such bioactive metabolites. Agrobacterium rhizogenes (Rhizobium rhizogenes) are virulent strains that often develop hairy roots. In vitro protocols are quite effective while growing co-cultivated explants to develop hairy roots. Since hairy roots potential for bioactive principles has been well documented, therefore, this particular review aims to highlight recent progress emphasizing feasibility and further potential applications in developing commodities for local and global markets.