<p>This research is based&#xa0;on the idea that certain cognitive-intensive tasks typically carried out by structural engineers—such as choosing how to effectively arrange a building’s structure—can be successfully automated. In this article we investigate two techniques widely used in the field of Artificial Intelligence, namely Monte Carlo Tree Search (MCTS) and Genetic Algorithm (GA). Following a tabula rasa approach, according to which no hints nor external data are used as a reference for navigating the search space, we demonstrate how structural designs of two-dimensional multi-storey reinforced concrete structures can be generated, with no human intervention, by implementing and combining the two techniques from a reinforcement-learning perspective. The design tasks assigned to the developed software agents concern civil structures under static and seismic loads, and the basis for comparison is represented by a combination of construction cost and greenhouse gas emissions associated with the making of the structures. In the article, based on the main concepts of Computational Mechanics, a theoretical framework is introduced, which allows to represent both structures and design tasks in a simple, analytical way. The process of gamification, to which MCTS is often associated, is then described, so that structural design is reduced to the concepts of state, actions and payoff.. Finally, case studies are presented in which different agents—based respectively on GA, MCTS, and a combination of both—are tested. The results suggest that hybrid approaches, where GA operates first followed by MCTS, are the most effective.</p>