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<p>This work aimed to bioprospect the antiproliferative activity of 13 ethyl acetate extracts of pigmented strains of phytopathogenic fungi of the genera <i>Epiccocum</i> and <i>Fusarium</i>. The antiproliferative activity of extracts was tested against six solid tumor cell lines: A-549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), T-47D (breast), and WiDr (colon). Ten extracts from strains of <i>Epicoccum sorghinum</i> (Sacc.) Aveskamp, Gruyter &amp; Verkley, <i>Epicoccum nigrum</i> Link, Didymellaceae, <i>Fusarium graminearum</i> Schwab, and <i>Fusarium</i> sp., Nectriaceae, showed antiproliferative activity against at least one cell line, with GI<sub>50</sub> values ≤ 50&#xa0;μg/ml. Three of them exhibited a strong antiproliferative activity (GI<sub>50</sub> &lt; 2.5&#xa0;μg/ml) against two cell lines. Furthermore, the extract of <i>E</i>. <i>sorghinum</i> showed a total growth inhibition (TGI) value &lt; 5&#xa0;μg/ml against the SW1573 and WiDr cell lines. The mycochemical study of this strain of <i>E. sorghinum</i> allowed the isolation and confirmation of the presence of the pigments altersolanol A and macrosporin, fungal metabolites previously reported with cytotoxic activity against cancer cells. While this work presents preliminary results related to the antiproliferative potential of pigment-producing phytopathogenic fungi, it fully opens the possibility of continuing to investigate these fungi as a source of substances with antiproliferative potential against cancer cell lines.</p> Graphical Abstract <p></p>

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Bioprospecting for Pigments Produced by Phytopathogenic Fungi with Antiproliferative Potential

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月12日

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  • Roberto Hernández-Chacón,
  • José M. Padrón,
  • Irene Lagunes,
  • César Espinoza,
  • Rosario Medel-Ortiz,
  • Lervin Hernández-Ramos,
  • Alejandro Salinas-Castro,
  • Ángel Trigos

摘要

This work aimed to bioprospect the antiproliferative activity of 13 ethyl acetate extracts of pigmented strains of phytopathogenic fungi of the genera Epiccocum and Fusarium. The antiproliferative activity of extracts was tested against six solid tumor cell lines: A-549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), T-47D (breast), and WiDr (colon). Ten extracts from strains of Epicoccum sorghinum (Sacc.) Aveskamp, Gruyter & Verkley, Epicoccum nigrum Link, Didymellaceae, Fusarium graminearum Schwab, and Fusarium sp., Nectriaceae, showed antiproliferative activity against at least one cell line, with GI50 values ≤ 50 μg/ml. Three of them exhibited a strong antiproliferative activity (GI50 < 2.5 μg/ml) against two cell lines. Furthermore, the extract of E. sorghinum showed a total growth inhibition (TGI) value < 5 μg/ml against the SW1573 and WiDr cell lines. The mycochemical study of this strain of E. sorghinum allowed the isolation and confirmation of the presence of the pigments altersolanol A and macrosporin, fungal metabolites previously reported with cytotoxic activity against cancer cells. While this work presents preliminary results related to the antiproliferative potential of pigment-producing phytopathogenic fungi, it fully opens the possibility of continuing to investigate these fungi as a source of substances with antiproliferative potential against cancer cell lines.

Graphical Abstract