<p>Currently there is no approved antiviral treatment for dengue virus, which continues to be a serious global health concern. Natural phytochemicals are a promising source of new compounds for developing antiviral drugs. Among these, the flavanone naringenin has drawn notice for its diverse range of pharmacological properties, such as antiviral, anti-inflammatory, and antioxidant effects. With an emphasis on dengue virus, this review combines experimental and computational studies to provide preliminary support for the therapeutic potential of naringenin. These integrated methods indicate that naringenin interferes with dengue virus replication by inhibiting key viral proteins. <i>In vitro</i> assays further support its dual targeting mechanism involving both viral and host pathways. Overall, current evidence suggests that naringenin is not yet a proven antiviral drug, but it may serve as a useful flavonoid compound that can help guide the development of new flavivirus inhibitors.</p> Graphical Abstract <p></p>