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<p><i>Centella asiatica</i> (L.) Urb., Apiaceae, is a treasure trove of phytochemicals, synthesizing distinctive triterpenoid derivatives such as asiaticoside and madecassoside, as well as bioactive flavonoid-polysaccharide complexes. This plant has transitioned from traditional wound-healing applications to promising multidimensional therapeutic prospects. Historically utilized in traditional Chinese medicine for inflammatory disorders, recent findings position this “neuroprotective herb” at the intersection of targeted therapeutic strategies and regulation of cellular metabolism. Our study presents the first comprehensive bibliometric synthesis of 1059 pharmacological publications (1997–2024), utilizing advanced scientometric tools (CiteSpace, VOSviewer) for temporal burst detection and knowledge domain visualization. The global collaborative network spans 76 countries, with notable hubs in China, India, and Korea, highlighting a shift from traditional phytochemistry to innovative applications targeting mitochondrial dysfunction (2019–2024, burst strength 24.3) and blood-brain barrier permeability. We identify three prominent research clusters: (1) triterpenoid glycosides as NLRP3 inflammasome regulators (centrality 0.89), (2) microbiota modulation in metabolic syndrome, and (3) nanoformulations for Alzheimer’s pathology. This analysis bridges traditional wisdom with contemporary therapeutic challenges, proposing a transdisciplinary roadmap that integrates systems biology and AI-driven drug discovery to fully harness <i>Centella</i>’s pharmacogenomic potential.</p> Graphical Abstract <p></p>

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Charting the Phytopharmacological Frontier of Centella asiatica: A Quarter-Century Bibliometric Atlas Unlocking Translational Potential

  • 期刊论文

  • 发表日期：

    2026年2月17日

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  • Junqi Yang,
  • Huan Zhu,
  • Qianbo Zhang,
  • Yuhe Dai,
  • Qiuyang Yao,
  • Xuqiang Nie

摘要

Centella asiatica (L.) Urb., Apiaceae, is a treasure trove of phytochemicals, synthesizing distinctive triterpenoid derivatives such as asiaticoside and madecassoside, as well as bioactive flavonoid-polysaccharide complexes. This plant has transitioned from traditional wound-healing applications to promising multidimensional therapeutic prospects. Historically utilized in traditional Chinese medicine for inflammatory disorders, recent findings position this “neuroprotective herb” at the intersection of targeted therapeutic strategies and regulation of cellular metabolism. Our study presents the first comprehensive bibliometric synthesis of 1059 pharmacological publications (1997–2024), utilizing advanced scientometric tools (CiteSpace, VOSviewer) for temporal burst detection and knowledge domain visualization. The global collaborative network spans 76 countries, with notable hubs in China, India, and Korea, highlighting a shift from traditional phytochemistry to innovative applications targeting mitochondrial dysfunction (2019–2024, burst strength 24.3) and blood-brain barrier permeability. We identify three prominent research clusters: (1) triterpenoid glycosides as NLRP3 inflammasome regulators (centrality 0.89), (2) microbiota modulation in metabolic syndrome, and (3) nanoformulations for Alzheimer’s pathology. This analysis bridges traditional wisdom with contemporary therapeutic challenges, proposing a transdisciplinary roadmap that integrates systems biology and AI-driven drug discovery to fully harness Centella’s pharmacogenomic potential.

Graphical Abstract