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<p><i>Helichrysum sanguineum</i> (L.) Kostel., Asteraceae, is a medicinal plant traditionally used for&#xa0;the treatment of several diseases, including asthma, tuberculosis, urogenital disorders, jaundice, dermatological inflammation, diarrhea, renal calculi, and fever. Phytochemical investigation of its aerial parts led to&#xa0;the isolation of four compounds, including one new <b>γ</b>-pyrone derivative named kadipyrone, which was identified as 2-(4-hydroxy-6-methylheptan-2-yl)-3-methyl-4<i>H</i>-pyran-4-one. Three known compounds were also isolated, including luteolin, quercetin and <i>p</i>-hydroxy benzoic acid. The structures of these compounds were elucidated through extensive spectroscopic methods, including ESI–MS, HR-ESI-(qTOF)-MS,<sup>1</sup>H NMR,<sup>13</sup>C NMR, APT-NMR experiments and two-dimensional NMR techniques (HSQC and HMBC). Furthermore, different fractions obtained from <i>H. sanguineum</i> and kadipyrone were evaluated for their anti-bacterial activity against <i>Helicobacter pylori</i> through a&#xa0;diffusion assay. The results indicated that kadipyrone has a promising activity toward <i>H. pylori</i><i>,</i> with a minimum inhibitory concentration of 32 µg/ml, suggesting its potential role in the treatment of <i>H. pylori</i> infection.</p> Graphical Abstract <p></p>

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Isolation of New Anti- Helicobacter pylori γ-Pyrone Derivative from Helichrysum sanguineum Based on Antimicrobial Profiling of Fractions

  • 期刊论文

  • 发表日期：

    2026年3月18日

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  • Adel M. Mahdi,
  • Taha A. Kedra,
  • Muhamad Abd-Elraouf,
  • Usama Shaheen,
  • Ezzat A. M. Genady

摘要

Helichrysum sanguineum (L.) Kostel., Asteraceae, is a medicinal plant traditionally used for the treatment of several diseases, including asthma, tuberculosis, urogenital disorders, jaundice, dermatological inflammation, diarrhea, renal calculi, and fever. Phytochemical investigation of its aerial parts led to the isolation of four compounds, including one new γ-pyrone derivative named kadipyrone, which was identified as 2-(4-hydroxy-6-methylheptan-2-yl)-3-methyl-4H-pyran-4-one. Three known compounds were also isolated, including luteolin, quercetin and p-hydroxy benzoic acid. The structures of these compounds were elucidated through extensive spectroscopic methods, including ESI–MS, HR-ESI-(qTOF)-MS,1H NMR,13C NMR, APT-NMR experiments and two-dimensional NMR techniques (HSQC and HMBC). Furthermore, different fractions obtained from H. sanguineum and kadipyrone were evaluated for their anti-bacterial activity against Helicobacter pylori through a diffusion assay. The results indicated that kadipyrone has a promising activity toward H. pylori, with a minimum inhibitory concentration of 32 µg/ml, suggesting its potential role in the treatment of H. pylori infection.

Graphical Abstract