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<p>We evaluated a combined oral formulation of black shallot extract and a micellar curcumin preparation for prevention of breast tumors in mice induced with 7,12-dimethylbenz[a]anthracene. After carcinogen exposure, animals received daily doses of the combined formulation at 100, 200, or 300 mg per kilogram for four weeks; an additional cohort received 300 mg per kilogram for four weeks and was then monitored without treatment for twenty-eight days. Outcomes included the number of tumors per mouse, total tumor mass, indicators of oxidative stress in mammary tissue (malondialdehyde and hydrogen peroxide), antioxidant defenses (reduced glutathione, total antioxidant capacity, superoxide dismutase, and catalase), and immune function (white-blood-cell count, nitroblue tetrazolium reduction, total immunoglobulin, and phagocytic activity). The combined formulation reduced tumor burden in a dose-dependent manner, with the highest dose lowering total tumor mass by approximately one-third and decreasing tumor number, while shifting oxidative and immune readouts toward a less pro-oxidant, more defensive state (<i>p</i> &lt; 0.05). Benefits in the satellite cohort were preserved through day fifty-six, suggesting durability after dosing stops. These findings support further investigation of this plant-based combination for long-term chemoprevention.</p> Graphical Abstract <p></p>

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Synergistic Dose-dependent Effects of Black Shallot and Nano-curcumin on Oxidative Stress and İmmune Modulation in a Murine Breast Cancer Model

  • 期刊论文

  • 发表日期：

    2025年12月20日

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  • Thi Phuong Nhung Tran,
  • Thi Hien Tran,
  • Thi Hoan Vu

摘要

We evaluated a combined oral formulation of black shallot extract and a micellar curcumin preparation for prevention of breast tumors in mice induced with 7,12-dimethylbenz[a]anthracene. After carcinogen exposure, animals received daily doses of the combined formulation at 100, 200, or 300 mg per kilogram for four weeks; an additional cohort received 300 mg per kilogram for four weeks and was then monitored without treatment for twenty-eight days. Outcomes included the number of tumors per mouse, total tumor mass, indicators of oxidative stress in mammary tissue (malondialdehyde and hydrogen peroxide), antioxidant defenses (reduced glutathione, total antioxidant capacity, superoxide dismutase, and catalase), and immune function (white-blood-cell count, nitroblue tetrazolium reduction, total immunoglobulin, and phagocytic activity). The combined formulation reduced tumor burden in a dose-dependent manner, with the highest dose lowering total tumor mass by approximately one-third and decreasing tumor number, while shifting oxidative and immune readouts toward a less pro-oxidant, more defensive state (p < 0.05). Benefits in the satellite cohort were preserved through day fifty-six, suggesting durability after dosing stops. These findings support further investigation of this plant-based combination for long-term chemoprevention.

Graphical Abstract