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<p><i>Gentiana veitchiorum</i> Hemsl, Gentianaceae, a valuable Tibetan medicinal plant, is renowned for its heat-clearing, detoxifying, and anti-inflammatory effects. Although its pharmacological properties are well-documented, comprehensive and comparative phytochemical analyses across different plant parts remain scarce. This study, for the first time, employed UHPLC-ESI-Q-TOF–MS/MS coupled with multivariate statistical analysis to systematically uncover the tissue-specific metabolic diversity in <i>G. veitchiorum</i>. A total of 35 compounds were identified, including iridoids, flavonoids, xanthones, triterpenoids, and lignans. The results revealed that the chemical composition of the root and rhizome, and stems of <i>G. veitchiorum</i> is highly similar, while both differ significantly from the leaves and flowers. This study identifies the active compounds responsible for the medicinal effects of <i>G. veitchiorum</i>, revealing the chemical composition differences between various plant parts. It provides important theoretical basis and data support for the quality evaluation, resource development, and comprehensive utilization of this plant.</p> Graphical Abstract <p></p>

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Study on the Diversity of Secondary Metabolites in Different Parts of Tibetan Medicine Gentiana veitchiorum Based on LC–MS Molecular Networking

  • 期刊论文

  • 发表日期：

    2025年12月23日

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  • Jiao Yin,
  • Liping Ruan,
  • Siman Gu,
  • Qing Shu,
  • Anzhong Peng,
  • Haifeng Li

摘要

Gentiana veitchiorum Hemsl, Gentianaceae, a valuable Tibetan medicinal plant, is renowned for its heat-clearing, detoxifying, and anti-inflammatory effects. Although its pharmacological properties are well-documented, comprehensive and comparative phytochemical analyses across different plant parts remain scarce. This study, for the first time, employed UHPLC-ESI-Q-TOF–MS/MS coupled with multivariate statistical analysis to systematically uncover the tissue-specific metabolic diversity in G. veitchiorum. A total of 35 compounds were identified, including iridoids, flavonoids, xanthones, triterpenoids, and lignans. The results revealed that the chemical composition of the root and rhizome, and stems of G. veitchiorum is highly similar, while both differ significantly from the leaves and flowers. This study identifies the active compounds responsible for the medicinal effects of G. veitchiorum, revealing the chemical composition differences between various plant parts. It provides important theoretical basis and data support for the quality evaluation, resource development, and comprehensive utilization of this plant.

Graphical Abstract