<p>Peptic disease has been one of the major illnesses affecting the global population, with high morbi-mortality. Nowadays, most therapeutic treatments have an effectiveness rate of around 20%. The leaves of the species <i>Monteverdia ilicifolia</i> (Mart. ex Reissek) Biral, Celastraceae (‘espinheira-santa’) are traditionally used in South America and Brazil to treat gastric ulcers, dyspepsia, and other gastric issues, yet clinical studies evaluating its efficacy in dyspepsia remain limited. This observational, uncontrolled study assessed the perception of 60 adult patients prescribed <i>M. ilicifolia</i> infusion for dyspeptic symptoms. The infusion was evaluated by chromatographic analysis with the pharmacopeial standard epicatechin. Symptom intensity was measured using a numerical scale (0–10) before and after treatment. Physicians were also surveyed regarding their confidence, training, and motivation in prescribing this herbal therapy. Statistical analyses included the Wilcoxon signed-rank test. All patients reported some symptom relief, with a mean reduction of 25.21 points in overall dyspeptic symptom scores (<i>p</i> &lt; 0.001). The most pronounced improvements were observed in heartburn and abdominal discomfort (median decrease: 6 points). Physicians were highly confident on the efficacy of <i>M. ilicifolia</i>; however, they felt uncomfortable prescribing it due to insufficient training. The presence of epicatechin was confirmed in the infusion of <i>M. ilicifolia</i>, in line with the quality standards of the Brazilian Pharmacopoeia. In conclusion, <i>M. ilicifolia</i> infusion was associated with significant symptom reduction in dyspeptic patients. Future randomized controlled trials are warranted to confirm efficacy.</p> Graphical Abstract <p></p>