<p>Brazilian green propolis has notable anti-inflammatory and neuroprotective properties, making it a potential candidate for treating neurological conditions. However, its impact on the sequelae of cerebral ischemia remains insufficiently explored. This study aimed to evaluate the effects of the hydroalcoholic extract of Brazilian green propolis dispersed in Poloxamer 188 (BGP-P188) on adult C57BL/6 mice subjected to bilateral common carotid artery occlusion, a model of transient global cerebral ischemia. Poloxamer 188 was selected as the surfactant due to the low solubility of hydroalcoholic extract, which could compromise its pharmacokinetic profile, reduce bioavailability and potentially limiting its neuroprotective effects. Male C57BL/6&#xa0;J mice were subjected to bilateral common carotid artery occlusion for 20&#xa0;min. Poloxamer 188 or the BGP-P188 at doses of 50, 100, and 150&#xa0;mg/kg was administered orally once daily for seven consecutive days. The animals were assessed for locomotor activity, anxiety-related and antidepressant-like behaviors of the treatments. Following the behavioral evaluations, the brains were collected to investigate the impact of BGP-P188 on neuronal death and neuroinflammation induced by bilateral common carotid artery occlusion. BGP-P188 (150&#xa0;mg/kg) decreased anxiety-like behavior induced by bilateral common carotid artery occlusion in mice. Also, BGP-P188 induced antidepressant-like effects in mice with bilateral common carotid artery occlusion. BGP-P188 mitigated hippocampal neuroinflammation induced by bilateral common carotid artery occlusion, as seen by a decreased immunoreactivity to both inflammatory markers, Iba-1 and glial fibrillary acid protein. These results suggest that BGP-P188 may present beneficial effects on the consequences of bilateral common carotid artery occlusion by decreasing hippocampal neuroinflammation.</p> Graphical Abstract <p></p>