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<p>Traditional Chinese Medicine offers a whole-system therapy for liver disease through multi-component, multi-pathway action. This review addresses the blending of Traditional Chinese Medicine with high-tech biomedical technologies, including molecular pathways, genetic data, and AI diagnosis. Effective Traditional Chinese Medicine, such as <i>Bupleurum</i> L., Apiaceae, <i>Salvia miltiorrhiza</i> Bunge, Lamiaceae, and <i>Schisandra chinensis</i> (Turcz.) Baill., Schisandraceae, modulate hepatic fibrosis, oxidative stress, and metabolic disorder through transforming growth factor beta/small mothers against decapentaplegic, nuclear factor kappa-light-chain-enhancer of activated B cells, and peroxisome proliferator-activated receptor alpha mechanisms. Artificial intelligence and machine learning algorithms assist Traditional Chinese Medicine–based treatment by recommending the best Herbal combination with 85–90% accuracy, while genomics-based targeted therapy tailors treatment to patatin-like phospholipase domain–containing protein 3, cytochrome P450 family 3 subfamily A member 4, and hydroxysteroid 17-beta dehydrogenase 13 polymorphism patients. Nanotechnology further increases the bioavailability of Hepatoprotectants, increasing absorption by 50–70%. Artificial intelligence–assisted diagnostics, wearable biosensors, and real-time metabolic monitoring will transform precision Traditional Chinese Medicine therapy. Although promising, there are issues regarding the standardization of herbal preparations, clinical data, and regulatory clearances. The direction of future research has to consider the integration of multi-omics data, artificial intelligence–facilitated optimization of herbal constituents, and well-designed clinical trials to ascertain the efficacy of Traditional Chinese Medicine as a therapeutic modality in liver disease. The review establishes the promise of artificial intelligence–facilitated, precision-medicine-based Traditional Chinese Medicine as a new paradigm for treating liver disease.</p> Graphical Abstract <p></p>

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Applications of Emerging Technologies in Traditional Chinese Medicine of Chronic Liver Disease: Nanotherapy Integration with Relevance to Artificial Intelligence and Genomics

  • 期刊论文

  • 发表日期：

    2025年10月27日

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  • Zongye Jiang,
  • Feng Xing

摘要

Traditional Chinese Medicine offers a whole-system therapy for liver disease through multi-component, multi-pathway action. This review addresses the blending of Traditional Chinese Medicine with high-tech biomedical technologies, including molecular pathways, genetic data, and AI diagnosis. Effective Traditional Chinese Medicine, such as Bupleurum L., Apiaceae, Salvia miltiorrhiza Bunge, Lamiaceae, and Schisandra chinensis (Turcz.) Baill., Schisandraceae, modulate hepatic fibrosis, oxidative stress, and metabolic disorder through transforming growth factor beta/small mothers against decapentaplegic, nuclear factor kappa-light-chain-enhancer of activated B cells, and peroxisome proliferator-activated receptor alpha mechanisms. Artificial intelligence and machine learning algorithms assist Traditional Chinese Medicine–based treatment by recommending the best Herbal combination with 85–90% accuracy, while genomics-based targeted therapy tailors treatment to patatin-like phospholipase domain–containing protein 3, cytochrome P450 family 3 subfamily A member 4, and hydroxysteroid 17-beta dehydrogenase 13 polymorphism patients. Nanotechnology further increases the bioavailability of Hepatoprotectants, increasing absorption by 50–70%. Artificial intelligence–assisted diagnostics, wearable biosensors, and real-time metabolic monitoring will transform precision Traditional Chinese Medicine therapy. Although promising, there are issues regarding the standardization of herbal preparations, clinical data, and regulatory clearances. The direction of future research has to consider the integration of multi-omics data, artificial intelligence–facilitated optimization of herbal constituents, and well-designed clinical trials to ascertain the efficacy of Traditional Chinese Medicine as a therapeutic modality in liver disease. The review establishes the promise of artificial intelligence–facilitated, precision-medicine-based Traditional Chinese Medicine as a new paradigm for treating liver disease.

Graphical Abstract