Scholarlink

<p>The diverse pharmacological properties of tectoridin and tectorigenin, two phytoestrogens derived from natural products, are highlighted in this review. Potent cytotoxic and antitumor agents effective against various malignancies, including prostate, breast, colon, lung, leukemia, ovarian, and liver cancers, are exhibited by tectoridin and tectorigenin through modulation of multiple signaling pathways involved in migration, apoptosis, cell proliferation, and invasion. Additionally, hepatoprotective, antihyperglycemic, and anti-alcoholism activities are demonstrated by tectoridin and tectorigenin. Despite their promising therapeutic potential, several shortcomings persist, including a lack of comprehensive understanding of their precise molecular mechanisms and toxicity, alongside challenges related to pharmacokinetics and formulation optimization. Future research should aim at elucidating the molecular biological targets of tectoridin and tectorigenin, comprehensive assessment of toxicity, developing innovative drug delivery systems, and making structural modifications to enhance their pharmacological efficacy and bioavailability. Overall, tectoridin and tectorigenin are promising natural compounds with multifaceted therapeutic applications, warranting further investigation to improve their clinical use.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Tectoridin and Tectorigenin: A Review of Their Chemistry, Biological Activities and Molecular Mechanisms

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月2日

查看全文
  • Shengguang Wang,
  • Yin Gao,
  • Peng Gao,
  • Zhen Li,
  • Zuorong Shi,
  • Shiming Zhang

摘要

The diverse pharmacological properties of tectoridin and tectorigenin, two phytoestrogens derived from natural products, are highlighted in this review. Potent cytotoxic and antitumor agents effective against various malignancies, including prostate, breast, colon, lung, leukemia, ovarian, and liver cancers, are exhibited by tectoridin and tectorigenin through modulation of multiple signaling pathways involved in migration, apoptosis, cell proliferation, and invasion. Additionally, hepatoprotective, antihyperglycemic, and anti-alcoholism activities are demonstrated by tectoridin and tectorigenin. Despite their promising therapeutic potential, several shortcomings persist, including a lack of comprehensive understanding of their precise molecular mechanisms and toxicity, alongside challenges related to pharmacokinetics and formulation optimization. Future research should aim at elucidating the molecular biological targets of tectoridin and tectorigenin, comprehensive assessment of toxicity, developing innovative drug delivery systems, and making structural modifications to enhance their pharmacological efficacy and bioavailability. Overall, tectoridin and tectorigenin are promising natural compounds with multifaceted therapeutic applications, warranting further investigation to improve their clinical use.

Graphical Abstract