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<p><i>Humulus lupulus</i> L., Cannabaceae, valued in the brewing industry for giving beer the characteristic bitterness, aroma, and flavor, has recently attracted interest for its biological activities. This study reviewed scientific articles and patents focused on dermatological applications of <i>H. lupulus</i> and xanthohumol, its main prenylated chalcone. A survey of articles and patents was performed on Scopus and Espacenet databases with the combination of terms “(<i>Humulus lupulus</i> or xanthohumol) and (skin* or cosmetic* or topic*)” and limited to materials published between 2009 and 2024. Twenty-five articles and 58 patents were included in this study. The patents were mainly from China, Japan, and South Korea and published mostly by companies. <i>Humulus lupulus</i> and its components display anti-inflammatory, antimicrobial, skin barrier–repairing, and anti-aging activities that may be relevant for dermatological applications. While scientific literature reported clinical properties, patents frequently focused on the potential cosmetic applications of <i>H. lupulus</i> and xanthohumol, <i>i.e.</i>, depigmenting and anti-aging properties. It is interesting to mention that technologies for hair or scalp were identified only in patents. This overview has compiled evidence that <i>H. lupulus</i> and xanthohumol possess scientific and market potential, as indicated by the analysis of articles and patents. These findings highlight promising possibilities for application within the pharmaceutical and cosmetic industries.</p> Graphical Abstract <p></p>

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Dermatological Uses of Humulus lupulus—A Review of Scientific and Technological Progress

  • 期刊论文

  • 发表日期：

    2025年7月5日

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  • Vitória Hana Müller Mottin,
  • Marina Cardoso Nemitz,
  • Bruna Medeiros-Neves,
  • Rochele Cassanta Rossi,
  • Jose Angelo Silveira Zuanazzi,
  • Gilsane Lino von Poser,
  • Helder Ferreira Teixeira

摘要

Humulus lupulus L., Cannabaceae, valued in the brewing industry for giving beer the characteristic bitterness, aroma, and flavor, has recently attracted interest for its biological activities. This study reviewed scientific articles and patents focused on dermatological applications of H. lupulus and xanthohumol, its main prenylated chalcone. A survey of articles and patents was performed on Scopus and Espacenet databases with the combination of terms “(Humulus lupulus or xanthohumol) and (skin* or cosmetic* or topic*)” and limited to materials published between 2009 and 2024. Twenty-five articles and 58 patents were included in this study. The patents were mainly from China, Japan, and South Korea and published mostly by companies. Humulus lupulus and its components display anti-inflammatory, antimicrobial, skin barrier–repairing, and anti-aging activities that may be relevant for dermatological applications. While scientific literature reported clinical properties, patents frequently focused on the potential cosmetic applications of H. lupulus and xanthohumol, i.e., depigmenting and anti-aging properties. It is interesting to mention that technologies for hair or scalp were identified only in patents. This overview has compiled evidence that H. lupulus and xanthohumol possess scientific and market potential, as indicated by the analysis of articles and patents. These findings highlight promising possibilities for application within the pharmaceutical and cosmetic industries.

Graphical Abstract