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<p>Probiotics demonstrate beneficial effects in age-related cognitive decline. In this study, two lactic oligomers, namely 2-((2-((2-hydroxypropanoyl)oxy)propanoyl)oxy)propanoic acid which is lactic acid trimer (<b>1</b>) and 2-((2-((2-((2-hydroxypropanoyl)oxy)propanoyl)oxy)propanoyl)oxy)propanoic acid&#xa0;which is lactic acid tetramer (<b>2</b>) were obtained from the ethyl acetate extract of the powdered heat-killed <i>Lacticaseibacillus paracasei</i> (HK-PS23). Besides, the current study explored the possible effect of HK-PS23 with probiotic potential on neuroprotection mediated by elevating the BDNF expression levels in Caco-2 cells. To evaluate this effect, Caco-2 cells were cultured with HK-PS23 and the isolated two lactic acid oligomers. Caco-2 treated with ethyl acetate extract of HK-PS23 in a concentration of 10&#xa0;μg/ml showed increased BDNF expression by nearly 3.5-fold. Moreover, lactic acid trimer (<b>1</b>) and lactic acid tetramer (<b>2</b>) obtained from HK-PS23 significantly enhanced the expression of the BDNF gene and consequently enhanced the production of BDNF in Caco-2 cells. In conclusion, the treatment with probiotic heat-killed <i>Lacticaseibacillus paracasei</i> and its isolated lactic acid derivatives contribute to neuronal development and proliferation via stimulation of BDNF production.</p> Graphical Abstract <p></p>

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Neuroprotective Potential of Lactic Acid Oligomers Derived from Heat-Killed Lacticaseibacillus paracasei HK-PS23

  • 期刊论文

  • 发表日期：

    2025年6月6日

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  • Yhiya Amen,
  • Chunguang Han,
  • Ahmed Othman,
  • Yanisa Mittraphab,
  • Dongmei Wang,
  • Maki Nagata,
  • Masako Matsumoto,
  • Shusaku Oka,
  • Jun Takehara,
  • Chien-Chen Wu,
  • Kuniyoshi Shimizu

摘要

Probiotics demonstrate beneficial effects in age-related cognitive decline. In this study, two lactic oligomers, namely 2-((2-((2-hydroxypropanoyl)oxy)propanoyl)oxy)propanoic acid which is lactic acid trimer (1) and 2-((2-((2-((2-hydroxypropanoyl)oxy)propanoyl)oxy)propanoyl)oxy)propanoic acid which is lactic acid tetramer (2) were obtained from the ethyl acetate extract of the powdered heat-killed Lacticaseibacillus paracasei (HK-PS23). Besides, the current study explored the possible effect of HK-PS23 with probiotic potential on neuroprotection mediated by elevating the BDNF expression levels in Caco-2 cells. To evaluate this effect, Caco-2 cells were cultured with HK-PS23 and the isolated two lactic acid oligomers. Caco-2 treated with ethyl acetate extract of HK-PS23 in a concentration of 10 μg/ml showed increased BDNF expression by nearly 3.5-fold. Moreover, lactic acid trimer (1) and lactic acid tetramer (2) obtained from HK-PS23 significantly enhanced the expression of the BDNF gene and consequently enhanced the production of BDNF in Caco-2 cells. In conclusion, the treatment with probiotic heat-killed Lacticaseibacillus paracasei and its isolated lactic acid derivatives contribute to neuronal development and proliferation via stimulation of BDNF production.

Graphical Abstract