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<p><i>Nigella sativa</i> L. belongs to the Ranunculaceae family and has a long history of medicinal use worldwide. Several studies have shown the pharmacological activities of <i>N. sativa</i> including, anti-inflammatory, anti-apoptosis, antimicrobial, and anti-oxidative effects. Ocular diseases affect the sense of vision and can lead to loss of visual acuity and blindness. This review aims to discuss the protective effect of <i>N. sativa</i> and its main constituent, thymoquinone, in ocular diseases and the mechanisms underlying these protective effects. Available evidence supports the therapeutic effects of <i>N. sativa</i> and thymoquinone in ocular diseases, <i>e.g</i>., in age-related macular degeneration, allergic conjunctivitis, dry eye, glaucoma, and cataracts. Future studies should confirm and extend the evidence of <i>N. sativa</i>’s efficacy in clinical practice against ocular diseases.</p> Graphical Abstract <p></p>

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Pharmacological Effects of Nigella sativa in Ocular Diseases

  • 期刊论文

  • 发表日期：

    2025年3月17日

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  • Fatemeh Forouzanfar,
  • Ali Mohammad Pourbagher-Shahri,
  • Elham Foroozanfar,
  • Mohamad Forouzanfar,
  • Ehsan Saburi,
  • Hassan Mehrad-Majd,
  • Zahra Tayarani-Najaran,
  • Hanie Mahaki,
  • Hamid TanzadehPanah,
  • Asma Afshari,
  • Abolfazl Shakeri

摘要

Nigella sativa L. belongs to the Ranunculaceae family and has a long history of medicinal use worldwide. Several studies have shown the pharmacological activities of N. sativa including, anti-inflammatory, anti-apoptosis, antimicrobial, and anti-oxidative effects. Ocular diseases affect the sense of vision and can lead to loss of visual acuity and blindness. This review aims to discuss the protective effect of N. sativa and its main constituent, thymoquinone, in ocular diseases and the mechanisms underlying these protective effects. Available evidence supports the therapeutic effects of N. sativa and thymoquinone in ocular diseases, e.g., in age-related macular degeneration, allergic conjunctivitis, dry eye, glaucoma, and cataracts. Future studies should confirm and extend the evidence of N. sativa’s efficacy in clinical practice against ocular diseases.

Graphical Abstract