<p>Medicinal plants have been essential to traditional medicine for their therapeutic benefits and potential in addressing age-related conditions associated with telomere shortening and cellular senescence. Telomere maintenance and telomerase activation are crucial for health and longevity, making these factors significant in the study of gerontology. This review aims to explore the impact of medicinal plants on telomerase activation and telomere maintenance, highlighting their potential role in mitigating aging and promoting longevity. <i>In vitro</i> and pre-clinical studies were evaluated to assess the role of these plants and compounds in telomere preservation. The literature review identified several medicinal plants and phytochemical compounds with notable rejuvenating properties. Evidence from <i>in vitro</i> and pre-clinical studies suggests that these plants and their compounds contribute to telomere maintenance and telomerase activation, supporting their potential as natural anti-aging therapies. Medicinal plants show promise in promoting health and longevity through mechanisms of telomere maintenance and telomerase activation. However, further research is needed to elucidate the precise mechanisms of action and determine the most effective plant-based interventions. Clinical trials are essential to assess the safety and efficacy of these natural therapies in extending lifespan and enhancing health.</p> Graphical Abstract <p></p>