Harmonizing Nature and Technology: Lipidic Nano-phytotherapeutics in the Management of Atopic Dermatitis

Atopic dermatitis is a widespread and chronic dermatological disorder that affects a significant portion of the global population. The intricate etiology and pathophysiology necessitate multifaceted therapeutic approaches. Although existing treatments provide relief, their high dosage requirements and elevated systemic titer contribute to alarming side effects, often leading to the discontinuation of conventional therapy. To mitigate these side effects, there is a shift of focus from systemic delivery to site-specific delivery, specifically topical delivery. Moreover, the multifaceted role of phytoconstituents proves beneficial in effectively targeting atopic dermatitis without inducing extensive side effects. However, the clinical exploration of phytoconstituents is hindered by their poor physicochemical properties. Therefore, it is intriguing to investigate how newer formulation technologies, such as nanotechnology, can contribute to the success of these phytoconstituents. This review highlights the emerging role of nanotechnology, particularly lipid-based nanotherapies, in optimizing drug delivery and potentially improving atopic dermatitis management. The integration of these lipid-based monotherapies with phytotherapeutics (lipidic phytonanotherapeutics) is explored as a promising avenue for enhanced therapeutic outcomes.