<p>Humidity sensors are essential for diverse applications such as health monitoring, agriculture, and food preservation, where high sensitivity, stability, and mechanical flexibility are often required. To integrate the advantages of organic and inorganic materials, we developed an organic–inorganic hybrid humidity sensor by tethering ethynyl-terminated P3HT (P3HT–≡) to 4-azidobenzoic acid (N₃-BA) capped CdSe tetrapods via a catalyst-free click reaction. The CdSe tetrapods serves as nanoscale scaffolds to provide a large surface area and improve charge transport. Formation of the nanocomposites was confirmed by ¹H-NMR, UV–vis, photoluminescence, and SEM analyses, showing intimate interfacial contact and uniform dispersion. The P3HT-CdSe tetrapod nanocomposites exhibited enhanced humidity sensing performance compared with both physical mixtures and pristine P3HT–≡, reaching a sensitivity of 228.2% at 70% relative humidity—over twice that of pristine P3HT–≡. The improved performance is attributed to efficient charge transfer, enlarged interfacial surface area, and homogeneous dispersion. This work highlights the promise of organic–inorganic hybrid nanocomposites for next-generation flexible and highly sensitive humidity sensors.</p> Graphical abstract <p>Hybrid P3HT–CdSe nanocomposites were synthesized via a catalyst-free click reaction, enabling intimate interfacial coupling, uniform dispersion, and efficient charge transfer between the organic polymer and inorganic nanocrystals. The resulting hybrid films exhibited enhanced humidity sensitivity and stability compared to conventional physical mixtures </p>