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<p><i>Mycoleptodonoides aitchisonii</i>, an edible mushroom, has health benefits; however, its long-term safety remains unclear. In this study, acute (single-dose) and 13-week repeated oral toxicity studies were performed in Sprague–Dawley rats. For the acute study, animals received single oral doses of 500, 1000, and 2000&#xa0;mg/kg. In the 13-week repeated-dose study, animals were administered 0, 500, 1000, and 2000&#xa0;mg/kg/day. No mortality or treatment-related adverse effects were detected. Minor alterations in hematology, serum chemistry, organ weights, and histopathology were occasionally observed and were considered toxicologically irrelevant. In conclusion, repeated oral administration of <i>M. aitchisonii</i> for 13&#xa0;weeks at doses up to 2000&#xa0;mg/kg/day did not adversely affect rats. Under these conditions, the no-observed-adverse-effect level of <i>M. aitchisonii</i> was established as ≥ 2000&#xa0;mg/kg/day in both sexes.</p>

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A 13-week repeated oral toxicity study of Mycoleptodonoides aitchisonii (Agaricomycetes) in Sprague–Dawley rats

  • 期刊论文

  • 发表日期：

    2026年4月5日

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  • In-Hyeon Kim,
  • Sung-Hwan Kim,
  • Joung-Wook Seo,
  • Young-Ju Lee,
  • Han Na Suh,
  • Jong-Choon Kim

摘要

Mycoleptodonoides aitchisonii, an edible mushroom, has health benefits; however, its long-term safety remains unclear. In this study, acute (single-dose) and 13-week repeated oral toxicity studies were performed in Sprague–Dawley rats. For the acute study, animals received single oral doses of 500, 1000, and 2000 mg/kg. In the 13-week repeated-dose study, animals were administered 0, 500, 1000, and 2000 mg/kg/day. No mortality or treatment-related adverse effects were detected. Minor alterations in hematology, serum chemistry, organ weights, and histopathology were occasionally observed and were considered toxicologically irrelevant. In conclusion, repeated oral administration of M. aitchisonii for 13 weeks at doses up to 2000 mg/kg/day did not adversely affect rats. Under these conditions, the no-observed-adverse-effect level of M. aitchisonii was established as ≥ 2000 mg/kg/day in both sexes.