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<p>Toxic substances can cause serious harm to aquatic organisms and humans who consume them. Rapid ecotoxicity assessment and genotoxicity assessment should be performed simultaneously to detect potential harm caused by toxic substances. In a previous study, an ecotoxicity and genotoxicity assessment system was established by treating fish cells derived from <i>Cyprinus carpio</i> (<i>C. carpio</i>) with toxic substances in a medium containing 1% fetal bovine serum (FBS) for 6&#xa0;h. In this study, these conditions (1% FBS/6&#xa0;h) were applied to fish cells derived from <i>Macropodus ocellatus</i> (<i>M. ocellatus</i>). Surprisingly, the new assessment tool using <i>M. ocellatus</i> cells provided ecotoxicity and genotoxicity data similar to those of <i>C. carpio</i> cells. In addition, the new assessment tool demonstrated its suitability as an assessment platform by demonstrating ecotoxicity and genotoxicity for substances known to be genotoxic (fluxapyroxad, fipronil, clarithromycin, 2,4-di-tert-butylphenol, perfluorooctanoic acid, prochloraz, abamectin, and climbazole). In conclusion, this study established an ecotoxicity and genotoxicity assessment system that can rapidly generate data. This assessment platform can be used as a tool to analyze a large number of toxins within a given period of time.</p>

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Rapid ecotoxicity and genotoxicity assessment using Macropodus ocellatus cells

  • 期刊论文

  • 发表日期：

    2025年11月18日

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  • Minseon Kim,
  • Ji Ho Park,
  • Byeonghyeon So,
  • Hojun Lee,
  • Jee Hee Yoon,
  • Yoo Jin Lee,
  • Duyeol Kim,
  • Hyung Wook Kwon,
  • Jihae Park,
  • Taejun Han,
  • Sekyung Oh,
  • Yun Haeng Lee,
  • Joon Tae Park

摘要

Toxic substances can cause serious harm to aquatic organisms and humans who consume them. Rapid ecotoxicity assessment and genotoxicity assessment should be performed simultaneously to detect potential harm caused by toxic substances. In a previous study, an ecotoxicity and genotoxicity assessment system was established by treating fish cells derived from Cyprinus carpio (C. carpio) with toxic substances in a medium containing 1% fetal bovine serum (FBS) for 6 h. In this study, these conditions (1% FBS/6 h) were applied to fish cells derived from Macropodus ocellatus (M. ocellatus). Surprisingly, the new assessment tool using M. ocellatus cells provided ecotoxicity and genotoxicity data similar to those of C. carpio cells. In addition, the new assessment tool demonstrated its suitability as an assessment platform by demonstrating ecotoxicity and genotoxicity for substances known to be genotoxic (fluxapyroxad, fipronil, clarithromycin, 2,4-di-tert-butylphenol, perfluorooctanoic acid, prochloraz, abamectin, and climbazole). In conclusion, this study established an ecotoxicity and genotoxicity assessment system that can rapidly generate data. This assessment platform can be used as a tool to analyze a large number of toxins within a given period of time.